L7895
リポポリサッカリド from Salmonella typhosa
γ-irradiated, BioXtra, suitable for cell culture
別名:
LPS
biological source
bacterial (Salmonella typhosa)
sterility
γ-irradiated
product line
BioXtra
form
lyophilized powder
purified by
gel-filtration chromatography
technique(s)
cell culture | mammalian: suitable
impurities
<1% Protein (Lowry)
color
white to faint yellow
solubility
water: 0.90-1.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow
storage temp.
2-8°C
Quality Level
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Application
リポポリサッカライド(LPS)は、グラム陰性菌の細胞壁を特徴とする構成成分です。LPSとその脂質A部分は、一般的な病原体関連分子パターン(PAMP)を認識するトール様受容体タンパク質ファミリーのメンバーであるトール様受容体4 (TLR4)によって、自然免疫系の細胞を刺激します。
Lipopolysaccharides from Salmonella typhosa are used in cell culture and cell binding applications. The role of LPS in the secretion of TNF-α and IL-6 was studied in mouse spleen cell culture. It was used to study the role of inflammatory responses in multiple sclerosis.
Biochem/physiol Actions
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).
Other Notes
To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
L7895-BULK: + L7895-1MG-PW: + L7895-VAR: + L7895-1MG:
jan
Joanne L Jones et al.
Brain : a journal of neurology, 133(Pt 8), 2232-2247 (2010-07-28)
Treatment of early relapsing-remitting multiple sclerosis with the lymphocyte-depleting humanized monoclonal antibody alemtuzumab (Campath [registered trade mark]) significantly reduced the risk of relapse and accumulation of disability compared with interferon β-1a in a phase 2 trial [Coles et al., (Alemtuzumab
D N Dao et al.
Infection and immunity, 72(4), 2067-2074 (2004-03-25)
The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as a virulence factor of Mycobacterium tuberculosis, and modification of the terminal arabinan residues of this compound with mannose caps (producing mannosyl-capped LAM [ManLAM]) in M. tuberculosis or with phosphoinositol
Yasuhisa Ano et al.
Scientific reports, 10(1), 20028-20028 (2020-11-20)
The prevention of age-related cognitive decline and dementia is becoming a high priority because of the rapid growth of aging populations. We have previously shown that hop bitter acids such as iso-α-acids (IAAs) and matured hop bitter acids (MHBAs) activate
Yasuhisa Ano et al.
Nutrients, 11(9) (2019-09-12)
The number of patients with mental illnesses is rapidly increasing, and daily lifestyle is closely associated with the development of symptoms. It is suggested that inflammatory molecules derived from microglia play crucial roles for the pathophysiology of depression. In the
Yasuhisa Ano et al.
Molecules (Basel, Switzerland), 24(3) (2019-01-31)
Inflammation in the brain is associated with various disorders including Alzheimer's disease and depression. Thus, inflammation has received increasing attention regarding preventive approaches to such disorders. Epidemiological investigations have reported that drinking tea reduces the risk of dementia and depression.
資料
Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.
関連コンテンツ
Datasheet
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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