M3655
D-マンノース 6-リン酸 ナトリウム塩
≥98% (HPLC)
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この商品について
化学式:
C6H12O9PNa
CAS番号:
分子量:
282.12
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352201
MDL number:
製品名
D-マンノース 6-リン酸 ナトリウム塩, ≥98% (HPLC)
InChI
1S/C6H13O9P.Na.H/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14;;/h1,3-6,8-11H,2H2,(H2,12,13,14);;
SMILES string
[Na].OC(COP(O)(O)=O)C(O)C(O)C(O)C=O
InChI key
RUFPTDNHMAGVMV-UHFFFAOYSA-N
biological source
synthetic (inorganic)
assay
≥98% (HPLC)
form
powder
technique(s)
HPLC: suitable
impurities
<12% water (Karl Fischer)
color
white
solubility
water: 50 mg/mL, clear to cloudy, colorless
cation traces
Na: 7.3-9.0% (anhydrous)
storage temp.
2-8°C
Quality Level
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Application
マンノースは in vivo での肺胞マクロファージの標的評価研究に用いられています。またホスホキャリアプロテイン NPr の遺伝子工学研究にも用いられています。
Biochem/physiol Actions
マンノース-6-P は免疫系においてレクチンが結合した分子です。マンノース-6-P はマンノースリン酸イソメラーゼによりフルクトース-6-リン酸に変換され、またリソソームへ運搬される酸性加水分解酵素前駆体タンパク質のための重要な標的シグナルとなります。
General description
マンノースは単糖類の1種です。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Yossef Lopez-de Los Santos et al.
The Journal of biological chemistry, 287(35), 29931-29939 (2012-07-07)
The Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system (PTS) in prokaryotes mediates the uptake and phosphorylation of its numerous substrates through a phosphoryl transfer chain where a phosphoryl transfer protein, HPr, transfers its phosphoryl group to any of several sugar-specific Enzyme IIA
Wei Cheong Ngeow et al.
Journal of anatomy, 219(5), 638-645 (2011-08-05)
Microsurgical repair of transected peripheral nerves is compromised by the formation of scar tissue and the development of a neuroma, thereby limiting the success of regeneration. The aim of this study was to quantify histomorphometrically the structural changes in neural
Petra Tiels et al.
Nature biotechnology, 30(12), 1225-1231 (2012-11-20)
Lysosomal storage diseases are treated with human lysosomal enzymes produced in mammalian cells. Such enzyme therapeutics contain relatively low levels of mannose-6-phosphate, which is required to target them to the lysosomes of patient cells. Here we describe a method for
Maria Francisca Coutinho et al.
Molecular genetics and metabolism, 105(4), 542-550 (2012-01-24)
Lysosomal hydrolases are synthesized in the rough endoplasmic reticulum and specifically transported through the Golgi apparatus to the trans-Golgi network, from which transport vesicles bud to deliver them to the endosomal/lysosomal compartment. The explanation of how are the lysosomal enzymes
Ningning Yang et al.
Journal of controlled release : official journal of the Controlled Release Society, 155(2), 326-330 (2011-07-19)
Triplex-forming oligonucleotides (TFOs) represent an antigene approach for gene regulation through direct interaction with genomic DNA. While this strategy holds great promise owing to the fact that only two alleles need silencing to impact gene regulation, delivering TFOs to target
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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