N1530
ノミフェンシン マレイン酸塩
dopamine uptake inhibitor , powder
別名:
1,2,3,4-テトラヒドロ-2-メチル-4-フェニル-8-イソキノリンアミン マレイン酸塩
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この商品について
実験式（ヒル表記法）:
C16H18N2 · C4H4O4
CAS番号:
分子量:
354.40
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
251-223-7
MDL number:
Form:
powder
Quality level:
製品名
ノミフェンシン マレイン酸塩,
InChI key
GEOCVSMCLVIOEV-BTJKTKAUSA-N
InChI
1S/C16H18N2.C4H4O4/c1-18-10-14(12-6-3-2-4-7-12)13-8-5-9-16(17)15(13)11-18;5-3(6)1-2-4(7)8/h2-9,14H,10-11,17H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES string
[H]\C(=C(/[H])C(O)=O)C(O)=O.CN1CC(c2ccccc2)c3cccc(N)c3C1
form
powder
Quality Level
Gene Information
human ... DBH(1621), SLC6A2(6530), SLC6A3(6531), SLC6A4(6532)
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関連するカテゴリー
Application
Nomifensine maleate salt has been used to study the β-CFT (cocaine analogue) binding using human embryonic kidney 293T cells.
Biochem/physiol Actions
Nomifensine maleate is a selective dopamine uptake inhibitor interacting with the dopamine transporter, at a site different from that of cocaine; antidepressant. Nomifensine serves as an antidepressant and is known to cause frequent hemolytic anemia. The aniline group in this compound results in blood and liver toxicities.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Yoonbae Oh et al.
Biosensors & bioelectronics, 121, 174-182 (2018-09-16)
For over two decades, fast-scan cyclic voltammetry (FSCV) has served as a reliable analytical method for monitoring dopamine release in near real-time in vivo. However, contemporary FSCV techniques have been limited to measure only rapid (on the order of seconds
Matthew Dunn et al.
Nature communications, 9(1), 2838-2838 (2018-07-22)
Norepinephrine is a monoamine neurotransmitter with a wide repertoire of physiological roles in the peripheral and central nervous systems. There are, however, no experimental means to study functional properties of individual noradrenergic synapses in the brain. Development of new approaches
S M Meiergerd et al.
Journal of neurochemistry, 63(5), 1683-1692 (1994-11-01)
The inhibition by cocaine of the apparent initial rate of the transport of striatal dopamine was compared with inhibitions produced by cocaethylene, benztropine, GBR-12909, mazindol, and nomifensine. Rotating disk electrode voltammetry was used to measure the kinetically resolved, inwardly directed
Metabolism of nomifensine to a dihydroisoquinolinium ion metabolite by human myeloperoxidase, hemoglobin, monoamine oxidase-A, and cytochrome P450 enzymes
Obach RS and Dalvie DK
Drug Metabolism and Disposition (2006)
Anders Borgkvist et al.
The international journal of neuropsychopharmacology, 15(4), 531-540 (2011-06-15)
Abnormal dopaminergic neurotransmission in the hippocampus may be involved in certain aspects of cognitive dysfunction. In the hippocampus, there is little, if any, expression of dopamine transporters (DAT), indicating that the mechanism for dopamine clearance differs from that in the
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