O2260
Mouse Osteopontin
recombinant, expressed in NSO cells, powder, suitable for cell culture
別名:
OPN, 分泌性ホスホプロテイン1(Spp1), 初期Tリンパ球活性化タンパク質-1(ETA-1), 骨シアロタンパク質-1
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この商品について
Biological source:
mouse
Form:
lyophilized powder
Technique(s):
cell culture | mammalian: suitable
Mol wt:
30 kDa by SDS-PAGE (reducing), 65 kDa by SDS-PAGE (reducing) (doublet)
Assay:
>95% (SDS-PAGE)
製品名
オステオポンチン マウス由来, >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
biological source
mouse
Quality Level
recombinant
expressed in NSO cells
sterility
sterile
assay
>95% (SDS-PAGE)
form
lyophilized powder
mol wt
30 kDa by SDS-PAGE (reducing), 65 kDa by SDS-PAGE (reducing) (doublet)
packaging
pkg of 50 μg
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
mouse ... Spp1(20750)
Application
Osteopontin from mouse has been used:
- to study its role in a mouse model of preterm brain injury
- as a positive control to analyze the relationship between the vascular calcification process and osteopontin (OPN) overexpression in the neointima of atherosclerotic plaques
- to study its interaction on the crystal growth process of hydroxyapatite in agarose hydrogels
Biochem/physiol Actions
Osteopontin (OPN) is a secreted, highly acidic, calcium binding, phosphorylated glycoprotein that is chemotactic for macrophages, smooth muscle cells, endothelial cells and glial cells. In activated macrophages, OPN inhibits nitric oxide production and cytotoxicity. Human, mouse, rat, pig and bovine OPN share 40% amino acid sequence identity.
Physical form
凍結乾燥品 (PBS溶液, 2.5mg BSA含有, 0.2μmフィルタ-滅菌済み)。
Analysis Note
生物活性は293細胞の細胞接着を仲介する能力により測定しています。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
O2260-VAR: + O2260-50UG-PW: + O2260-50UG: + O2260-BULK:
jan
Osteopontin upregulation in atherogenesis is associated with cellular oxidative stress triggered by the activation of scavenger receptors
Jimenez CAE, et al.
Archives of Medical Research, 43(2), 102-111 (2012)
Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival
Denhardt DT, et al.
The Journal of Clinical Investigation, 107(9), 1055-1061 (2001)
The effect of osteopontin and osteopontin-derived peptides on preterm brain injury
Albertsson AM, et al.
Journal of Neuroinflammation, 11(1), 197-197 (2014)
Effect of osteopontin, chondroitin sulfates (B, C), and human serum albumin on the crystallization behavior of hydroxyapatite in agarose and silica hydrogels
Jimenez CAE, et al.
Crystal Growth & Design, 8(4), 1335-1339 (2008)
Yunan Zhu et al.
Japanese journal of infectious diseases, 68(6), 467-473 (2015-04-14)
The level of osteopontin (OPN) increases during bacterial lung infection. However, the OPN level in virus-induced lung injury is unclear, and the relationship between the hyer-production of OPN and lung injury remains to be thoroughly understood. Therefore, we sought to
関連コンテンツ
Datasheet
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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