O4264
Human Osteopontin
recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
別名:
OPN, 分泌性ホスホプロテイン1(Spp1), 初期Tリンパ球活性化タンパク質-1(ETA-1), 骨シアロタンパク質1
ログインで組織・契約価格をご覧ください。
サイズを選択してください
この商品について
Biological source:
human
Form:
lyophilized powder
Technique(s):
cell culture | mammalian: suitable
Mol wt:
60-65 kDa by SDS-PAGE (reducing)
Assay:
≥95% (SDS-PAGE)
製品名
オステオポンチン ヒト, recombinant, expressed in NSO cells, ≥95% (SDS-PAGE), lyophilized powder, suitable for cell culture
biological source
human
Quality Level
recombinant
expressed in NSO cells
sterility
sterile
assay
≥95% (SDS-PAGE)
form
lyophilized powder
mol wt
60-65 kDa by SDS-PAGE (reducing)
packaging
pkg of 50 μg
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
shipped in
ambient
storage temp.
−20°C
Gene Information
human ... SPP1(6696)
General description
Secreted phosphoprotein 1 (SPP1) or osteopontin is a secreted cytokine. This phosphorylated acidic glycoprotein is expressed in various cells and tissues. It is synthesized by osteoblasts. The gene encoding SPP1 is localized on human chromosome 4q22.1.
Application
Anti-Osteopontin antibody produced in rabbit has been used for ELISA.
Biochem/physiol Actions
A secreted, highly acidic, calcium binding, phosphorylated glycoprotein that is chemotactic for macrophages, smooth muscle cells, endothelial cells, and glial cells. In activated macrophages, OPN inhibits nitric oxide production and cytotoxicity. Human, mouse, rat, pig, and bovine OPN share 40% amino acid sequence identity. Secreted phosphoprotein 1 (SPP1) or osteopontin modulates inflammatory responses and glucose metabolism. It is a chemotactic factor and has a role in immune cell recruitment. The protein is also associated with cell growth, migration and differentiation. SPP1 attaches osteoclasts to the bone matrix. It is also involved in atherosclerotic process and bone mineralization. It is a marker of many cancers.
Physical form
凍結乾燥品 (PBS溶液, 2.5mg BSA含有, 0.2μmフィルタ-濾過)。
Analysis Note
293細胞に対する接着作用により生物活性を測定しています。
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Osteopontin Fragments with Intact Thrombin-Sensitive Site Circulate in Cervical Cancer Patients
Danny TM
PLoS ONE (2016)
Expanded comparative mapping between man
and rabbit and detection of a new conserved
segment between HSA22 and OCU4
and rabbit and detection of a new conserved
segment between HSA22 and OCU4
C Chantry
Cytogenetic and genome research (2005)
Polycystic ovary syndrome is associated with increased osteopontin levels
European Journal of Endocrinology (2015)
Comparison of Plasma Osteopontin Levels between Patients with Borderline Ovarian Tumours and Serous Ovarian Carcinoma.
Zivny JH
Folia Biologica (Praha.) (2016)
Yunan Zhu et al.
Japanese journal of infectious diseases, 68(6), 467-473 (2015-04-14)
The level of osteopontin (OPN) increases during bacterial lung infection. However, the OPN level in virus-induced lung injury is unclear, and the relationship between the hyer-production of OPN and lung injury remains to be thoroughly understood. Therefore, we sought to
関連コンテンツ
Datasheet
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）