O9512
オキサリプラチン
Apoptosis inducer, powder
別名:
[SP-4-2-(1R-trans)]-(1,2-シクロヘキサンジアミン-N,N′)[エタンジオアタ(2--)-O,O′]白金
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この商品について
製品名
オキサリプラチン, powder
form
powder
Quality Level
originator
Sanofi Aventis
storage temp.
2-8°C
SMILES string
O=C1O[Pt]OC1=O.N[C@@H]2CCCC[C@H]2N
InChI
1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1
InChI key
ZROHGHOFXNOHSO-BNTLRKBRSA-L
Application
- 結腸直腸腺癌SW480細胞において細胞生存率アッセイによる化学療法剤として
- 肝細胞癌HepG2及びHepG2/R細胞においてMTTアッセイにより細胞生存をモニタリングするため
- ヒト乳腺癌MDA-MB-231細胞への成長抑制作用を判定するため
Biochem/physiol Actions
Features and Benefits
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signalword
Danger
Hazard Classifications
Carc. 2 - Eye Dam. 1 - Lact. - Muta. 2 - Repr. 1B - Resp. Sens. 1B - Skin Sens. 1 - STOT RE 1
保管分類
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
資料
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.