P0039
PHPS1 ナトリウム塩 水和物
≥98% (HPLC)
別名:
4-[2-[1,5-ジヒドロ-3-(4-ニトロフェニル)-5-オキソ-1-フェニル-4H-ピラゾール-4-イリデン]ヒドラジニル]-ベンゼンスルホン酸 ナトリウム塩 水和物
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この商品について
実験式（ヒル表記法）:
C21H15N5O6S · xNa+ · yH2O
CAS番号:
分子量:
465.44 (anhydrous free acid basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
color
red
solubility
DMSO: 10 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
O=C1/C(C(C2=CC=C([N+]([O-])=O)C=C2)=NN1C3=CC=CC=C3)=N/NC4=CC=C(S(=O)([O-])=O)C=C4.[Na+].O
InChI
1S/C21H15N5O6S.Na.H2O/c27-21-20(23-22-15-8-12-18(13-9-15)33(30,31)32)19(14-6-10-17(11-7-14)26(28)29)24-25(21)16-4-2-1-3-5-16;;/h1-13,22H,(H,30,31,32);;1H2/q;+1;/p-1/b23-20+;;
InChI key
KLXUVMQUEDKCKG-JBKNFAMTSA-M
Application
Phenylhydrazono pyrazolone sulfonate 1 (PHPS1) sodium salt hydrate has been used as a protein-tyrosine phosphatase (shp2) inhibitor to study its effects on bisphenol A (BPA) and nonyl phenol (NP)-induced cell proliferation of MCF7 cell. It has also been used as a shp2 inhibitor to study its pro-atherosclerotic or atheroprotective effect in vivo and in vitro.
Biochem/physiol Actions
Phenylhydrazono pyrazolone sulfonate 1 (PHPS1) represses E2-induced gene transcription and rapid DNA synthesis. It also blocks mitogen-activated protein kinase (ERK1/2) activation and reduces the cigarette smoke induced-inflammatory response in mouse lungs.
Shp-2は成長因子のシグナル伝達を制御するSrcホモロジー2(SH2)含有ホスファターゼです。
Shp-2は成長因子のシグナル伝達を制御するSrcホモロジー2(SH2)含有ホスファターゼです。この酵素は哺乳動物組織に広範に発現し、発達において必須の役割を果たします。また、様々な病態にも関与します。PHPS1はShp-2の選択的インヒビターであり、Shp-2依存的な下流のシグナル伝達をブロックします。
Features and Benefits
This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
保管分類
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
資料
Protein tyrosine phosphatases' catalytic mechanism involves transient phosphorylation.
Chunmei Fan et al.
Cell reports, 39(4), 110762-110762 (2022-04-28)
Tendon maturation lays the foundation for postnatal tendon development, its proper mechanical function, and regeneration, but the critical cell populations and the entangled mechanisms remain poorly understood. Here, by integrating the structural, mechanical, and molecular properties, we show that post-natal
SHP2 inhibitor PHPS1 protects against atherosclerosis by inhibiting smooth muscle cell proliferation
Chen J, et al.
BMC Cardiovascular Disorders, 18(1), 72-72 (2018)
Increased Cell Proliferation by Various Doses of Xenoestrogen in MFC-7 Cell Through Tyrosine Phosphatase Shp2
Liu W, et al.
American Journal of Bioscience and Bioengineering, 3(6), 178-182 (2015)