PENK
ペニシリンG カリウム塩
95.0 - 102.0%
別名:
ベンジルペニシリン カリウム塩
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この商品について
実験式（ヒル表記法）:
C16H17KN2O4S
CAS番号:
分子量:
372.48
UNSPSC Code:
51283424
NACRES:
NA.85
PubChem Substance ID:
EC Number:
204-038-0
Beilstein/REAXYS Number:
3832841
MDL number:
InChI
1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1
InChI key
IYNDLOXRXUOGIU-LQDWTQKMSA-M
SMILES string
[K+].[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)Cc3ccccc3)C([O-])=O
assay
95.0 - 102.0%
form
powder
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell wall synthesis | interferes
Quality Level
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関連するカテゴリー
Application
Penicillin G is a narrow spectrum antibiotic derived from Streptococcus pneumoniae. It is the drug of choice for groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridians group streptococci, and non-penicillinase producing staphylococcus. The potassium salt has been used to study murosomes of staphylococci† and the penicillin-induced lysis of Streptococcus mutans†.
Biochem/physiol Actions
作用機序：ペニシリンGは、ペニシリン結合タンパク質(PBP)結合によって細胞壁の合成を阻害して作用し、ペプチドグリカン鎖の架橋を阻害します。
抗菌スペクトル：本製品は、グラム陽性菌とグラム陰性菌のいずれにも対抗する活性を示します。
抗菌スペクトル：本製品は、グラム陽性菌とグラム陰性菌のいずれにも対抗する活性を示します。
Packaging
1mu,10mu,100mu
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Handle and store under inert gas. Keep in a dry place.Very soluble in water, slightly soluble in ethanol (96%), practically insoluble in methylene chloride
Disclaimer
Solutions should be filter sterilized and stored at 2-8°C for 1 week or at -20°C for more lengthy periods. Solutions are stable at 37°C for 3 days.
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
PENK-BULK: + PENK-VAR: + PENK-100MU: + PENK-1MU: + PENK-10MU: + PENK-25MU:
jan
T A Kral et al.
Infection and immunity, 46(2), 442-447 (1984-11-01)
Treatment of Streptococcus mutans GS-5 cells with concentrations of penicillin G within a relatively narrow range resulted in substantial lysis. This penicillin-induced lysis was dependent upon cell density and pH of the lysis medium. Other oral streptococci (Streptococcus sobrinus, Streptococcus
P Giesbrecht et al.
Journal of bacteriology, 174(7), 2241-2252 (1992-04-01)
Electron microscopic research into the murosomes of staphylococci has shown that the number of murosomes involved in penicillin-induced death varies depending on the experimental conditions employed. With 0.1 micrograms of penicillin G per ml, only 1 of a total of
Mariagrazia Perilli et al.
Antimicrobial agents and chemotherapy, 57(2), 1047-1049 (2012-11-28)
Two laboratory mutant forms, TEM-149(H240) and TEM-149(H164-H240), of the TEM-149 extended-spectrum β-lactamase enzyme were constructed by site-directed mutagenesis. TEM-149(H240) and TEM-149(H164-H240) were similar in kinetic behavior, except with respect to benzylpenicillin and ceftazidime. Molecular modeling of the two mutant enzymes
Eleonor G Lago et al.
Sexually transmitted diseases, 40(2), 85-94 (2013-01-18)
The aim of this study was to investigate clinical features and outcomes of children treated for congenital syphilis (CS). Infants born alive in the public sector of São Lucas Hospital, Porto Alegre, Brazil, 1997 to 2004, whose mothers had syphilis
Congenital syphilis: the story of a greek tragedy.
Sarah Hawkes
Sexually transmitted diseases, 40(2), 95-96 (2013-01-17)
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