S2064
SC-560
≥98% (HPLC)
別名:
5-(4-クロロフェニル)-1-(4-メトキシフェニル)-3-トリフルオロメチルピラゾール
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この商品について
実験式（ヒル表記法）:
C17H12ON2ClF3
CAS番号:
分子量:
352.74
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
製品名
SC-560, ≥98% (HPLC)
InChI key
PQUGCKBLVKJMNT-UHFFFAOYSA-N
SMILES string
COc1ccc(cc1)-n2nc(cc2-c3ccc(Cl)cc3)C(F)(F)F
InChI
1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3
assay
≥98% (HPLC)
solubility
DMSO: >20 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
human ... PTGS1(5742), PTGS2(5743)
関連するカテゴリー
Biochem/physiol Actions
シクロオキシゲナ-ゼ-1 (COX-1) の選択的インヒビタ-であり、 COX-2と比較してCOX-1に700倍の選択性を示します。
SC-560 (5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole) is a non-steroidal anti-inflammatory drug (NSAID). It is a lipophilic, diaryl heterocyclic compound. SC-560 acts as an effective antiviral agent against hepatitis C virus (HCV). It also has a potential to hinder prostaglandin E2 synthesis in neurons at nanomolar concentrations.
SC-560 belongs to the diaryl heterocycle class of cyclooxygenase (COX) inhibitors. It exhibits anti-tumor and anti-proliferative activities.
Application
SC-560 has been used as a cyclooxygenase-1 (COX-1) inhibitor to study its effects on prostaglandin E-2 (PGE2) signaling in ciliogenesis in zebrafish embryos. It has also been used as a selective inhibitor of COX-1 to study its role in PM10-induced endothelial dysfunction.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Dan Wang et al.
Antioxidants (Basel, Switzerland), 11(5) (2022-05-29)
Nuclear factor erythroid factor E2-related factor 2 (Nrf2) transcribes antioxidant genes that reduce the blood pressure (BP), yet its activation with tert-butylhydroquinone (tBHQ) in mice infused with angiotensin II (Ang II) increased mean arterial pressure (MAP) over the first 4
G O'Callaghan et al.
British journal of cancer, 99(3), 502-512 (2008-07-24)
Fas ligand (FasL/CD95L) is a member of the tumour necrosis factor superfamily that triggers apoptosis following crosslinking of the Fas receptor. Despite studies strongly implicating tumour-expressed FasL as a major inhibitor of the anti-tumour immune response, little is known about
Edwin S L Chan et al.
Arthritis research & therapy, 9(1), R4-R4 (2007-01-25)
Both selective cyclooxygenase (COX)-2 inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs) have been beneficial pharmacological agents for many patients suffering from arthritis pain and inflammation. However, selective COX-2 inhibitors and traditional NSAIDs are both associated with heightened risk of myocardial infarction.
Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport
Jin D, et al.
Nature Cell Biology, 16(9), 841-851 (2014)
Anti-bovine viral diarrhoea virus and hepatitis C virus activity of the cyclooxygenase inhibitor SC-560
Okamoto M, et al.
Antiviral Chemistry & Chemotherapy, 20(1), 47-54 (2009)
関連コンテンツ
Instructions
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