S4069
SL 327
≥98% (HPLC), Mixture of E & Z isomers, solid
別名:
α-[アミノ-(4-アミノフェニルチオ)メチレン)-2-(トリフルオロメチル)フェニルアセトニトリル
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この商品について
実験式（ヒル表記法）:
C16H12F3N3S
CAS番号:
分子量:
335.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
製品名
SL 327, ≥98% (HPLC), Mixture of E & Z isomers, solid
InChI
1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
SMILES string
N\C(Sc1ccc(N)cc1)=C(\C#N)c2ccccc2C(F)(F)F
InChI key
JLOXTZFYJNCPIS-FYWRMAATSA-N
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
protect from light
color
white to off-white
mp
127-128.2 °C
solubility
DMSO: >10 mg/mL
H2O: insoluble
storage temp.
2-8°C
Quality Level
関連するカテゴリー
Biochem/physiol Actions
SL327はMEK1/2の選択的インヒビター(それぞれのIC50値はMEK1が 0.18 μM、MEK2が 0.22 μM)であり、in vitroで海馬のLTPを遮断します。
SL327はMEK1/2の選択的インヒビター(それぞれのIC50値はMEK1が0.18 μM、MEK2が0.22 μM)であり、in vitroで海馬のLTPを遮断します。また、SL327は脳透過性を有することからin vivoでラットの恐怖条件付けや学習をブロックするほか、マウスの全身投与では神経保護作用を発揮しています。
Application
SL327 has been used as an inhibitor of dual specificity mitogen-activated protein kinase (MEK) in Zebrafish embryos and lymphatic endothelial cell (LEC).
SL327 was used to study the role of MAPK signaling in interictal spiking and behavior of epileptic rats. It was used to study the effect of estradiol on ERK signaling in mouse dorsal hippocampus.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
劇物
pdsc
S4069-VAR: + S4069-5MG:4548173218113 + S4069-25MG:4548173218106 + S4069-IP: + S4069-BULK:
jan
Stephanie M Fernandez et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(35), 8660-8667 (2008-08-30)
The extracellular signal-regulated kinase (ERK) pathway is critical for various forms of learning and memory, and is activated by the potent estrogen 17beta-estradiol (E(2)). Here, we asked whether E(2) modulates memory via ERK activation and putative membrane-bound estrogen receptors (ERs).
Lin Grimm et al.
eLife, 8 (2019-05-01)
Lymphatic vascular development involves specification of lymphatic endothelial progenitors that subsequently undergo sprouting, proliferation and tissue growth to form a complex second vasculature. The Hippo pathway and effectors Yap and Taz control organ growth and regulate morphogenesis and cellular proliferation.
Gisela Borges et al.
The international journal of neuropsychopharmacology, 20(6), 463-463 (2017-02-06)
There is increasing evidence suggesting that the Locus Coeruleus plays a role in pain-related anxiety. Indeed, we previously found that prolonged arthritis produces anxiety-like behavior in rats, along with enhanced expression of phosphorylated extracellular signal-regulated kinase 1/2 (a marker of
Daniel T Barkmeier et al.
Neurobiology of disease, 47(1), 92-101 (2012-04-05)
Epilepsy is a disease characterized by chronic seizures, but is associated with significant comorbidities between seizures including cognitive impairments, hyperactivity, and depression. To study this interictal state, we characterized the electrical, molecular, and behavior effects of chronic, neocortical interictal spiking
Daniel A Lee et al.
Science advances, 5(11), eaax4249-eaax4249 (2019-11-26)
The genetic bases for most human sleep disorders and for variation in human sleep quantity and quality are largely unknown. Using the zebrafish, a diurnal vertebrate, to investigate the genetic regulation of sleep, we found that epidermal growth factor receptor
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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