ブドウ球菌エンテロトキシンB Staphylococcus aureus由来

MHCクラスII分子およびＴ細胞受容体（TCR）の特異的Vβ領域に結合し、単球／マクロファージおよびTリンパ球の両方の活性化をもたらすStaphylococcal enterotoxin B（ブドウ球菌エンテロトキシンB）（SEB）は、超抗原および免疫系活性化剤として使用される場合があります。 SEBは、SEB検出システムの開発において標準物質として使用される場合があります。

Tリンパ球に対するスーパー抗原。 主要組織適合性複合体（MHC）抗原およびCD28に結合する免疫系の活性化剤。

容量はタンパク質含有量に基づいています。

Staphylococcal Enterotoxin B (SEB) is a potent exotoxin produced by Staphylococcus aureus, classified as a superantigen due to its unique ability to activate T-cells non-specifically. This activation occurs through the cross-linking of T-cell receptors (TCRs) and major histocompatibility complex (MHC) class II molecules, leading to a massive release of cytokines and an exaggerated immune response. SEB is associated with food poisoning and toxic shock syndrome, making it a critical agent for studying the mechanisms of bacterial pathogenesis and immune dysregulation.
In addition to its role in infectious disease research, SEB serves as a valuable tool for investigating autoimmune conditions and the development of immunotherapies. Its ability to induce T-cell activation and proliferation makes it an important reagent for exploring T-cell biology, including differentiation, memory formation, and the effects of various immunomodulators.