S5013
サルブタモール ヘミ硫酸塩
≥98%
別名:
α-([t-ブチルアミノ]メチル)-4-ヒドロキシ-m-キシレン-α,α′-ジオール, アルブテロール
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この商品について
化学式:
C13H21NO3 · 1/2H2SO4
CAS番号:
分子量:
288.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
256-916-8
MDL number:
Assay:
≥98%
Quality level:
Quality Level
assay
≥98%
solubility
1 M NaOH: 50 mg/ml, clear to slightly hazy, yellow-green
originator
GlaxoSmithKline
SMILES string
OS(O)(=O)=O.CC(C)(C)NCC(O)c1ccc(O)c(CO)c1.CC(C)(C)NCC(O)c2ccc(O)c(CO)c2
InChI
1S/2C13H21NO3.H2O4S/c2*1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;1-5(2,3)4/h2*4-6,12,14-17H,7-8H2,1-3H3;(H2,1,2,3,4)
InChI key
BNPSSFBOAGDEEL-UHFFFAOYSA-N
Gene Information
human ... ADRB2(154)
Application
Salbutamol hemisulfate salt was used as standard in analysis of fortified meat for LABA content using ELISA kits.3 It was used to study the response of prostaglandin 2α to various β-adrenergic agonists in cultured bovine endometrial cells.4
Salbutamol hemisulfate salt has been used as reference standards of drugs for the validation of β-agonist residue.
Biochem/physiol Actions
β2-Adrenergic receptor agonist.
Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP).1 Salbutamol is particularly effective in treatment of asthma as it provides immediate relief.2
Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP). Salbutamol is particularly effective in treatment of asthma as it provides immediate relief. Salbutamol is one of the most popular short-acting BA (SABA). It is useful in treating the symptoms of EIB (exercise induced bronchospasm).
Features and Benefits
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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signalword
Warning
hcodes
Hazard Classifications
Carc. 2 - Repr. 2 - Skin Sens. 1
保管分類
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
R S Pirie et al.
Journal of veterinary pharmacology and therapeutics, 40(3), 231-238 (2016-09-07)
Despite frequent use of metered dose inhalers (MDIs) and spacers in equine practice, limited information exists on the efficiency of aerosol delivery using such devices. We determined the particle size distribution within an MDI-generated salbutamol aerosol delivered via an equine
Medical and pharmacological approach to adjust the salbutamol anti-doping policy in athletes
Pillard F, et al.
Respiratory Research, 16(1), 155-155 (2015)
Validation of ELISA test kits for detection of beta-agonist residues in meat
Ponniah J, et al.
The Southeast Asian Journal of Tropical Medicine and Public Health, 35(1), 481-487 (2004)