S7395
スピペロン
solid
別名:
8-[3-(p-フルオロベンゾイル)プロピル]-1-フェニル-1,3,8-トリアザスピロ[4.5]デカン-4-オン, R 5147, スピロペリドール
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この商品について
実験式（ヒル表記法）:
C23H26FN3O2
CAS番号:
分子量:
395.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
212-024-0
MDL number:
Form:
solid
Quality level:
form
solid
Quality Level
color
light yellow
solubility
H2O: slightly soluble 0.2 mg/mL, 0.1 M HCl: slightly soluble 0.3 mg/mL, ethanol: 1.5 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2 mg/mL
SMILES string
Fc1ccc(cc1)C(=O)CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4
InChI
1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29)
InChI key
DKGZKTPJOSAWFA-UHFFFAOYSA-N
Gene Information
General description
Spiperone is a butyrophenone antipsychotic agent. It induces calcium-dependent chloride secretion in the airway and functions as a potential therapeutic target for cystic fibrosis.
Application
Spiperone was used to study the role of dopamine receptors in facilitating the male sexual behavior in quails.6
Spiperone has been used to block the actions of 5-hydroxytryptamine (5-HT) receptor. It also has been used to study its anti tumor effects in glioblastoma (GBM) cell lines.
Biochem/physiol Actions
D2ド-パミンレセプタ-の選択的アンタゴニストであり、α1B-アドレナリンレセプタ-のアンタゴニストです。また5-HT2A/5-HT1セロトニンレセプタ-の混合アンタゴニストです。抗精神病薬です。
Preparation Note
溶液は、4°Cで1～2日間は保存することができます。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway
Lu D and Carson DA
BioMed Central Pharmacology, 9(1), 13-13 (2009)
Marion Schuller et al.
ChemMedChem, 12(19), 1585-1594 (2017-08-05)
MS Binding Assays are a label-free alternative to radioligand binding assays. They provide basically the same capabilities as the latter, but use a non-labeled reporter ligand instead of a radioligand. In contrast to radioligand binding assays, MS Binding Assays offer-owing
Spiperone, identified through compound screening, activates calcium-dependent chloride secretion in the airway
Liang L, et al.
American Journal of Physiology. Cell Physiology, 296(1), C131-C141 (2009)
I S Geerts et al.
British journal of pharmacology, 127(6), 1327-1336 (1999-08-24)
In humans intimal thickening is aprerequisite of atherosclerosis. Application of a silicone collar around the rabbit carotid artery induces an intimal thickening but in addition it increases the sensitivity to the vasoconstrictor action of serotonin (5-hydroxytryptamine, 5-HT). The 5-HT receptors
Carmen Klein Herenbrink et al.
Nature communications, 7, 10842-10842 (2016-02-26)
Biased agonism describes the ability of ligands to stabilize different conformations of a GPCR linked to distinct functional outcomes and offers the prospect of designing pathway-specific drugs that avoid on-target side effects. This mechanism is usually inferred from pharmacological data
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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