S8825
サラーマイド
≥98% (HPLC)
別名:
N-{3-[(2-ヒドロキシ-ナフタレン-1-イルメチレン)-アミノ]-フェニル}-2-フェニル-プロピオンアミド
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この商品について
実験式（ヒル表記法）:
C26H22N2O2
CAS番号:
分子量:
394.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
yellow
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
CC(C(=O)Nc1cccc(c1)\N=C\c2c(O)ccc3ccccc23)c4ccccc4
InChI
1S/C26H22N2O2/c1-18(19-8-3-2-4-9-19)26(30)28-22-12-7-11-21(16-22)27-17-24-23-13-6-5-10-20(23)14-15-25(24)29/h2-18,29H,1H3,(H,28,30)/b27-17+
InChI key
HQSSEGBEYORUBY-WPWMEQJKSA-N
Application
Salermide was used to treat human pulmonary artery smooth muscle cells to study the effect of SIRT1 inhibition on expression of atrogin by qPCR.1
Biochem/physiol Actions
サレルミドはサーチュイン1(Sirt1)およびサーチュイン2(Sirt2)の新規インヒビターです(クラスIIIヒストン脱アセチル化酵素インヒビター)。In vitroにおいてサレルミドはSirt1よりもSirt2に強い阻害効果を示します。サレルミドは腫瘍細胞で広範なアポトーシスを誘導します。この活性は、Sirt1により癌細胞のみにおいてエピジェネティックに抑制されるアポトーシス促進性遺伝子がサレルミドの効果により再活性化されるためとみなされています。サレルミド(salermide)はサーチュインのインヒビターとしてサーチノール(製品番号S7942)よりも強力です。
サレルミドはサーチュイン1(Sirt1)およびサーチュイン2(Sirt2)の新規インヒビターです。サレルミドは、Sirt1により癌細胞のみにおいてエピジェネティックに抑制されるアポトーシス促進性遺伝子を再活性化します。
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
保管分類
11 - Combustible Solids
wgk
WGK 3
資料
We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.
Qi Zhang et al.
EMBO molecular medicine, 4(4), 298-312 (2012-02-15)
Although ∼50% of all types of human cancers harbour wild-type TP53, this p53 tumour suppressor is often deactivated through a concerted action by its abnormally elevated suppressors, MDM2, MDMX or SIRT1. Here, we report a novel small molecule Inauhzin (INZ)
Mohammad Reza Salahshoor et al.
International journal of preventive medicine, 4(12), 1402-1413 (2014-02-06)
Sirtuin1 is an enzyme that deacetylates histones and several non-histone proteins including P53 during the stress. P300 is a member of the histone acetyl transferase family and enzyme that acetylates histones. Hereby, this study describes the potency combination of Salermide
Julien Lancelot et al.
PLoS neglected tropical diseases, 7(9), e2428-e2428 (2013-09-27)
The chemotherapy of schistosomiasis currently depends on the use of a single drug, praziquantel. In order to develop novel chemotherapeutic agents we are investigating enzymes involved in the epigenetic modification of chromatin. Sirtuins are NAD+ dependent lysine deacetylases that are