抗TRPC1 ウサギ宿主抗体

Transient receptor potential cation channel subfamily C member 1 (TRPC1) is encoded by the gene mapped to human chromosome 3q22-24. The encoded protein is a member of the transient receptor potential (TRP) superfamily of cation channels and is distributed in both glomeruli and glomerular mesangial cells.

ヒトTRPC1(Genbank^®Accession No. P48995)のアミノ酸557-571に相当する合成ペプチド。エピトープはマウス、ラットと同一であり、ウシおよびアフリカツメガエル(Xenopus)と高い相同性があります。

Transient receptor potential cation channel subfamily C member 1 (TRPC1) facilitates Ca²⁺ entry upon store depletion in a variety of cell types by forming a multimeric complex with other TRPCs. The encoded protein is implicated in the odontoblast-like differentiation of human dental pulp cells (hDPCs). Mutation in the gene is associated with the development type 2 diabetes mellitus (T2D). Decreased expression of the gene leads to hepatocellular carcinoma cell proliferation and thus, TRPC1 can be considered as a potential therapeutic target for hepatocellular carcinoma.

凍結乾燥品 (0.3 mg/mLのPBS溶液, pH 7.4, 1%BSA, 5%スクロ-ス, 0.025%アジ化ナトリウム含有)。

GenBank is a registered trademark of United States Department of Health and Human Services

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.