T8325
TDZD-8
≥98% (HPLC), needles
別名:
4-ベンジル-2-メチル-1,2,4-チアジアゾリジン-3,5-ジオン
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この商品について
実験式（ヒル表記法）:
C10H10N2O2S
CAS番号:
分子量:
222.26
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
製品名
TDZD-8, ≥98% (HPLC), needles
InChI
1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
SMILES string
CN1SC(=O)N(Cc2ccccc2)C1=O
InChI key
JDSJDASOXWCHPN-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
needles
storage condition
protect from light
color
white
mp
63-64.4 °C
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
Quality Level
関連するカテゴリー
Biochem/physiol Actions
GSK-3の選択的インヒビタ-であり、チアジアゾリジノン誘導体です。GSK-3βの非ATP競合阻害剤です(IC50 = 2 μM)。濃度100 μM以上でCdk-1/サイクリンB, CK-II, PKA, PKCに対する阻害はありません。GSK-3βのキナ-ゼ部位に結合するといわれています。
TDZD-8 is a selective inhibitor of GSK-3.
Application
TDZD-8 has been used to study the role of GSK-3 in maintaining MLL leukemia stem cell transcriptional program. TDZD-8 has also been used to analyze its effect on neural functions of the mouse olfactory bulb.
Features and Benefits
This compound is featured on the GSK-3 page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Preparation Note
TDZD-8 is soluble in DMSO at a concentration that is greater than 10 mg/ml.
保管分類
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
T8325-5MG: + T8325-VAR: + T8325-25MG: + T8325-BULK:
jan
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Many uncommon non-methylene-interrupted fatty acids (NMI FA) are present in limpet gonads, but their biological properties remain unknown. To investigate new biological effects of naturally occurring NMI FA in eukaryotic cells, the biological activities of structurally analogous (4Z,15Z)-octadecadienoic acid (1)
Lydia Hannou et al.
Journal of biological rhythms, 33(2), 166-178 (2018-04-20)
NEUROLIGIN-1 (NLGN1) is a postsynaptic adhesion molecule involved in the regulation of glutamatergic transmission. It has been associated with several features of sleep and psychiatric disorders. Our previous work suggested that transcription of the Nlgn1 gene could be regulated by
Teng Jiang et al.
Inflammation, 41(3), 811-823 (2018-01-25)
As a recently identified susceptibility gene for Alzheimer's disease (AD), triggering receptor expressed on myeloid cells 2 (TREM2) encodes an immune receptor that is uniquely expressed on microglia, functioning as a modulator of microglial functions including phagocytosis and inflammatory response.
Qing Yu et al.
Cell death & disease, 15(1), 73-73 (2024-01-19)
Chronic stress and elevated levels of glucocorticoids (GCs), the main stress hormones, accelerate Alzheimer's disease (AD) onset and progression. A major driver of AD progression is the spreading of pathogenic Tau protein between brain regions, precipitated by neuronal Tau secretion.
Yujia Wang et al.
Perfusion, 33(8), 679-686 (2018-07-11)
Sevoflurane has been shown to protect against myocardial ischemia/reperfusion (I/R) injury in animals, while its cardioprotection is lost if the ischemic insult is too long. In this study, we proposed a prevailing hypothesis that GSK-3β inhibitor-mediated activation of GSK-3β/β-catenin signaling
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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