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Merck

PHR1187

Tretinoin

Pharmaceutical Secondary Standard; Certified Reference Material

동의어(들):

Retinoic acid, ATRA, Tretinoin, Vitamin A acid, all-trans-Retinoic acid

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크기 선택

제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C20H28O2
CAS 번호:
302-79-4
Molecular Weight:
300.44
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823197
EC Number:
206-129-0
Beilstein/REAXYS Number:
2057223
MDL number:
MFCD00001551

주요 문서

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InChI key

SHGAZHPCJJPHSC-YCNIQYBTSA-N

InChI

1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+

SMILES string

CC1=C(\C=C\C(C)=C\C=C\C(C)=C\C(O)=O)C(C)(C)CCC1

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. T1850000, traceable to USP 1674004

API family

tretinoin

form

solid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

180-181 °C (lit.)

application(s)

food and beverages

format

neat

storage temp.

-10 to -25°C

Quality Level

300

Gene Information

human ... RARA(5914), RARB(5915), RARG(5916)

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관련 카테고리

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards. Tretinoin is a medication used for the treatment of severe cystic acne. The drug acts by regulating epithelial cell growth and differentiation, sebum production, collagen synthesis and keratinization of the skin.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Tretinoin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

Biochem/physiol Actions

all−trans−Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR). The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells. Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA. Retinoic acid primes embryonic stem cells to become neurons.
Ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR); primes embryonic stem cells to become neurons.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB7354 in the slot below. This is an example certificate only and may not be the lot that you receive.

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B - Skin Irrit. 2

저장 등급

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Tretinoin assay in cosmetics and pharmaceuticals by carbon phase extraction
Ragno G, et al.
Journal of the Society of Cosmetic Chemists, 47(5), 325-325 (1996)
Simultaneous determination of minoxidil and tretinoin in pharmaceutical and cosmetic formulations by reversed-phase HPLC
Gagliardi L, et al.
Analytical Letters, 24(10), 1825-1835 (1991)
Solid lipid nanoparticles (SLN) of tretinoin: potential in topical delivery
Shah KA, et al.
International Journal of Pharmaceutics, 345(1-2), 163-171 (2007)
Analysis and stability study of retinoids in pharmaceuticals by LC with fluorescence detection
Gatti R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 23(1), 147-159 (2000)
A rapid HPLC method for simultaneous determination of tretinoin and isotretinoin in dermatological formulations
Tashtoush BM, et al.
Journal of Pharmaceutical and Biomedical Analysis, 43(3) (2007)
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