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Merck

PHR1010

Propylparaben

Pharmaceutical Secondary Standard; Certified Reference Material

Synonyme(s) :

Propyl 4-hydroxybenzoate, 4-Hydroxybenzoic acid propyl ester, Propyl paraben

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A propos de cet article

Formule linéaire :
HOC6H4CO2CH2CH2CH3
Numéro CAS:
94-13-3
Poids moléculaire :
180.20
NACRES:
NA.24
E Number:
E216
PubChem Substance ID:
329823041
UNSPSC Code:
41116107
EC Number:
202-307-7
MDL number:
MFCD00002354
Beilstein/REAXYS Number:
1103245

Principaux documents

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Nom du produit

Propylparaben, Pharmaceutical Secondary Standard; Certified Reference Material

InChI

1S/C10H12O3/c1-2-7-13-10(12)8-3-5-9(11)6-4-8/h3-6,11H,2,7H2,1H3

InChI key

QELSKZZBTMNZEB-UHFFFAOYSA-N

SMILES string

CCCOC(=O)c1ccc(O)cc1

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. P3650000
traceable to USP 1577008

API family

parabens

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

95-98 °C (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Catégories apparentées

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Propylparaben is the benzoate ester, widely used as a preservative in personal care products.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC2080 in the slot below. This is an example certificate only and may not be the lot that you receive.

hcodes

H412

Hazard Classifications

Aquatic Chronic 3

Classe de stockage

11 - Combustible Solids

wgk

WGK 1

flash_point_f

356.0 °F

flash_point_c

180 °C

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Hye-Min Kang et al.
Chemosphere, 226, 388-394 (2019-04-05)
Parabens are used as a preservative substance in a wide range of man-made products causing deleterious effects on aquatic organisms and therefore, the concern of their effects to aquatic organisms has been increased. In this study, acute toxicity of methylparaben
Michelle P Dvores et al.
Langmuir : the ACS journal of surfaces and colloids, 28(17), 6978-6984 (2012-03-29)
This study presents a method for one-step formation of poly(ethylene oxide) nanofibers incorporating nanoparticles of a poorly water-soluble compound. Using the new method reported here, nanofiber-nanoparticle composites are fabricated in one step by electrospinning of an oil-in-water microemulsion, in which
Dennis G Maki et al.
Critical care medicine, 39(4), 613-620 (2011-01-05)
Catheter-related bloodstream infection is the greatest threat to the safety of patients on hemodialysis. Catheter lock solutions containing heparin have been linked to an increased risk of hemorrhage and thrombocytopenia. To ascertain the safety and efficacy for prevention of catheter-related
Aeshna Amin et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 75(2), 206-212 (2010-03-09)
p-Hydroxybenzoic acid esters (parabens) are commonly used antimicrobial preservatives in pharmaceutical formulations. Two microorganisms, isolated from non-sterile methyl paraben (MP) and propyl paraben (PP) solutions, were found to degrade the respective parabens. Identification by 16S rRNA partial gene sequencing revealed
C L Barberis et al.
Journal of food protection, 73(8), 1493-1501 (2010-09-08)
Each year, a significant portion of the peanuts produced cannot be marketed because of fungal disease at the postharvest stage and mycotoxin contamination. Antioxidants could be used as an alternative to fungicides to control ochratoxigenic fungi in peanuts during storage.
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