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Merck

PHR1048

4-Hydroxybenzoic acid

Pharmaceutical Secondary Standard; Certified Reference Material

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A propos de cet article

Formule linéaire :
HOC6H4CO2H
Numéro CAS:
99-96-7
Poids moléculaire :
138.12
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823078
EC Number:
202-804-9
Beilstein/REAXYS Number:
970950
MDL number:
MFCD00002547

Principaux documents

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Nom du produit

4-Hydroxybenzoic acid, Pharmaceutical Secondary Standard; Certified Reference Material

InChI

1S/C7H6O3/c8-6-3-1-5(2-4-6)7(9)10/h1-4,8H,(H,9,10)

InChI key

FJKROLUGYXJWQN-UHFFFAOYSA-N

SMILES string

OC(=O)c1ccc(O)cc1

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to USP 1609013

API family

4-hydroxybenzoic acid

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

213-217 °C (lit.)

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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Catégories apparentées

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. 4-Hydroxybenzoic acid belongs to the class of aromatic acids, which may be used as a preservative in cosmetics, pharmaceuticals and as a synthetic flavoring agent in food products.
This compound can be found as a component in plants of the genus: aloe, carum, cinnamomum, lycium, thymus

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB2176 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

hcodes

H318,H335

Hazard Classifications

Eye Dam. 1 - STOT SE 3

target_organs

Respiratory system

Classe de stockage

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Handbook of Preservatives (2004)
M G Soni et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 39(6), 513-532 (2001-05-11)
Propyl paraben (CAS no. 94-13-3) is a stable, non-volatile compound used as an antimicrobial preservative in foods, drugs and cosmetics for over 50 years. It is an ester of p-hydroxybenzoate. Propyl paraben is readily absorbed via the gastrointestinal tract and
L C Goudas et al.
Anesthesia and analgesia, 89(5), 1209-1215 (1999-11-30)
Intracerebroventricular (ICV) morphine administration is effective for the management of refractory cancer pain. Recent preclinical observations of acute depletion of the major endogenous intracellular antioxidant glutathione (GSH) in brain and peripheral organs after ICV morphine in rodents led us to
Letian X Xie et al.
The Journal of biological chemistry, 287(28), 23571-23581 (2012-05-18)
Most of the Coq proteins involved in coenzyme Q (ubiquinone or Q) biosynthesis are interdependent within a multiprotein complex in the yeast Saccharomyces cerevisiae. Lack of only one Coq polypeptide, as in Δcoq strains, results in the degradation of several
Suri Roowi et al.
Molecular nutrition & food research, 53 Suppl 1, S68-S75 (2009-05-06)
Human urine was collected over a 24 h period after the consumption of 250 mL of (i) water, (ii) orange juice, and (iii) orange juice plus 150 mL of full fat natural yoghurt. The orange juice contained 168 micromol of
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