This collection of Application Notes has been produced by SeQuant® scientists or developed by customers to assist you in the analysis of your compound. Each application note focuses on separation of a specific compound or type of compound with recommendations for the best column and separation conditions to use. Examples of expected data are also included.
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Small Molecule Bioanalysis by LC-MS and LC-MS/MS
Analysis of endogenous and exogenous compounds in biological samples
Polar Hydrophilic Compounds in Pharmaceutical Analysis – Part II
Monograph modernization using SeQuant® ZIC®
Food Safety and Food Quality Control
Analysis of Polar Compounds in Complex Samples
Polar Hydrophilic Compounds in Pharmaceutical Analysis
SeQuant® ZIC®-HILIC HPLC for control of active ingredients, impurities, counterions, and excipients.
LCGC-EU April 2003 Separation of Morphine and Glucuronated Metabolites on a Bonded Zwitterionic Stationary Phase
LCGC-EU March 2005 Mass Spectrometric Detection of Homocysteine, Methylmalonic Acid and Succinic Acid using HILIC on a Zwitterionic Stationary Phase
LCGC-EU May 2004 Separation of Polar and Hydrophilic Compounds Using a Zwitterionic Stationary Phase in HILIC
LCGC-NA Sept 2004 Separation of Polar and Hydrophilic Compounds Using a Zwitterionic Stationary Phase in HILIC
LCGC-NA Aug 2006 Simultaneous Determination of Positive and Negative Counterions Using a Hydrophilic Interaction Chromatography Method
2800-02B ZIC®-pHILIC Separation of Flavonoids
2800-03B ZIC®-pHILIC Separation of Adenosine Phosphates
2800-04B ZIC®-pHILIC Separation of Aliphatic Amino Acids
2800-05B ZIC®-pHILIC Separation of Fumaric Oxalic and Citric Acid
2800-06B ZIC®-pHILIC Separation of Nucleotides using ZIC-pHILIC and Negative ESI-MS
2800-07B ZIC®-pHILIC Separation of Purines and Pyrimidines
2800-08B ZIC®-pHILIC Separation of Tartaric and Ascorbic Acid
2800-09B ZIC®-pHILIC Separation of Angiotensin II Bradykinin and Gly-His-Lys
2800-10B ZIC®-pHILIC Separation of Fructose Glucose Sucrose and Lactose
2800-11B ZIC®-pHILIC Gradient Separation of Fructose Glucose Sucrose and Lactose