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203800 Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 76939-46-3 - Calbiochem

Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt, CAS 76939-46-3, is a cell-permeable cAMP analog with greater resistance to phosphodiesterases. Preferentially activates protein kinase A.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.

Synonyme: 8-Bromo-cAMP, Na

Primary Target: PKA
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203800
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
76939-46-3C₁₀H₁₀BrN₅O₆P · Na

Preis & Verfügbarkeit

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203800-10MG
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      Description
      OverviewCell-permeable cAMP analog that has greater resistance to phosphodiesterases than cAMP. Preferentially activates protein kinase A (PKA). Directly activates Epac, a Rap1 guanine-nucleotide exchange factor.
      Catalogue Number203800
      Brand Family Calbiochem®
      Synonyms8-Bromo-cAMP, Na
      References
      ReferencesKawasaki, H., et al. 1998. Science 282, 2275.
      de Rooij, J., et al. 1998. Nature 396, 474.
      Boyer, B., and Thiery, J.P. 1993. J. Cell Biol. 120, 767.
      Hei, Y.-J., et al. 1991. Mol. Pharmacol. 39, 233.
      Product Information
      CAS number76939-46-3
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₀H₁₀BrN₅O₆P · Na
      Chemical formulaC₁₀H₁₀BrN₅O₆P · Na
      HS Code2934 99 99
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationAdenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt, CAS 76939-46-3, is a cell-permeable cAMP analog with greater resistance to phosphodiesterases. Preferentially activates protein kinase A.
      Biological Information
      Primary TargetPKA
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid pH >8.5.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      203800-10MG 04055977203998

      Documentation

      Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 76939-46-3 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Adenosine 3ʹ,5ʹ-cyclic Monophosphate, 8-Bromo-, Sodium Salt - CAS 76939-46-3 - Calbiochem Analysenzertifikate

      TitelChargennummer
      203800

      Literatur

      Übersicht
      Kawasaki, H., et al. 1998. Science 282, 2275.
      de Rooij, J., et al. 1998. Nature 396, 474.
      Boyer, B., and Thiery, J.P. 1993. J. Cell Biol. 120, 767.
      Hei, Y.-J., et al. 1991. Mol. Pharmacol. 39, 233.

      Literaturstellen

      Titel
    • Michael J. Cross, et al. (2002) The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells. Molecular Biology of the Cell 13, 2881-2893.
      		•
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-May-2008 RFH
      Synonyms8-Bromo-cAMP, Na
      DescriptionCell-permeable cAMP analog that is more resistant to phosphodiesterases than cAMP. Preferentially activates cAMP-dependent protein kinase (PKA). Induces the guanine-nucleotide-exchange factor activity of GEFI, also known as Epac (exchange protein directly activated by cAMP), and GEFII toward Rap1 both in vivo and in vitro.
      FormWhite solid
      CAS number76939-46-3
      Chemical formulaC₁₀H₁₀BrN₅O₆P · Na
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid pH >8.5.
      Toxicity Standard Handling
      ReferencesKawasaki, H., et al. 1998. Science 282, 2275.
      de Rooij, J., et al. 1998. Nature 396, 474.
      Boyer, B., and Thiery, J.P. 1993. J. Cell Biol. 120, 767.
      Hei, Y.-J., et al. 1991. Mol. Pharmacol. 39, 233.
      Citation
    • Michael J. Cross, et al. (2002) The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells. Molecular Biology of the Cell 13, 2881-2893.
      		•