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ABN487 Anti-JPH3 Antibody

Anti-JPH3 Antibody is a highly specific rabbit polyclonal antibody, that targets Junctophilin-3 & has been tested in western blotting, IHC & Immunofluorescence.

Anti-JPH3 Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: JPH3, JP3, TNRC22 UniProt Number: Q8WXH2
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ABN487
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHC, IFRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN487
      DescriptionAnti-JPH3 Antibody
      Alternate Names
      • Junctophilin-3
      • JP-3
      • Junctophilin type 3
      • Trinucleotide repeat-containing gene 22 protein
      • JPH3
      Background InformationJunctophilin-3 (JPH3, JP-3), also known as Trinucleotide repeat-containing gene 22 protein (TNRC22), is a single-pass type IV membrane protein belonging to the junctophilin family. Junctophilins are important components of the junctional complexes which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. JPH3 is specifically expressed in brain. A mutation associated with JPH3 is the cause of Huntington disease-like type 2 (HDL2), a neurodegenerative disorder.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Daudi cell lysate
      PresentationPurified rabbit polyclonal antibody in buffer containing PBS with 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-JPH3 Antibody is a highly specific rabbit polyclonal antibody, that targets Junctophilin-3 & has been tested in western blotting, IHC & Immunofluorescence.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunofluorescence
      Application NotesImmunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected JPH3 in human brain tissue.
      Immunofluorescence Analysis: 20 μg/mL from a representative lot detected JPH3 in human brain cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to a sequence near the C-terminus of human JPH3.
      EpitopeNear C-terminus.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes the C-terminus of JPH3.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • JPH3
      • JP3
      • TNRC22
      Purification MethodAffinity purified.
      UniProt Number
      Molecular Weight~105 kDa observed. Uniprot describes 2 isoforms at ~20 kDa and ~81 kDa. Uncharacterized bands may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting/Peptide Inhibition Assay in Daudi cell lysate.

      Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected JPH3 in 15 µg of Daudi cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABN487 04053252901232