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MAB3314 Anti-MT3-MMP Antibody, Chemicon, purified mouse monoclonal, clone 117-10C6.

Anti-MT3-MMP Antibody, clone 117-10C6 detects level of MMP-16 & has been published & validated for use in WB.

SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Cell Structure Research Sub-Category: MMPs & TIMPs Gene Symbol: MMP16, MMPX2, MMP-16, MT3MMP, MT-MMP3, MT3-MMP, MTMMP3, MMP-X2, MT-MMP2, EC 3.4.24.- UniProt Number: P51512
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MAB3314
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB3314
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-MT3-MMP Antibody, Chemicon, purified mouse monoclonal, clone 117-10C6.
      Alternate Names
      • MT3-MMP
      References
      Product Information
      FormatPurified
      PresentationLiquid in 0.1 M sodium phosphate buffer, pH 7.0 containing 2% protease free bovine serum albumin.
      Quality LevelMQ100
      Applications
      ApplicationAnti-MT3-MMP Antibody, clone 117-10C6 detects level of MMP-16 & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesImmunoblotting
      Biological Information
      ImmunogenThis antibody was made to an oligopeptide of EEVPYSELENGKRD (residue 168-181) on human membrane-type 3 matrix metalloproteinase (human MT3-MMP).
      Clone117-10C6
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThe antibody specifically reacts with human MT3-MMP. This is a purified mouse monoclonal antibody to an oligopeptide of EEVPYSELENGKRD (residue 168-181) on human membrane-type 3 matrix metalloproteinase (human MT3-MMP).
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryProteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene produces at least two transcripts, one which encodes a membrane-bound form and another a soluble form of the protein. Both forms of the protein activate MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.
      Gene Symbol
      • MMP16
      • MMPX2
      • MMP-16
      • MT3MMP
      • MT-MMP3
      • MT3-MMP
      • MTMMP3
      • MMP-X2
      • MT-MMP2
      • EC 3.4.24.-
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P51512 # Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. The short isoform cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
      COFACTOR: Binds 1 zinc ion per subunit (By similarity). & Calcium (By similarity).
      SIZE: 607 amino acids; 69521 Da
      SUBUNIT: Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.
      SUBCELLULAR LOCATION: Isoform Long: Cell membrane; Single-pass type I membrane protein (Potential). Note=Localized at the cell surface of melanoma cells. & Isoform Short: Secreted. Cell surface. Note=Localized at the cell surface of melanoma cells.
      TISSUE SPECIFICITY: Expressed in heart, brain, placenta, ovary and small intestine. The short isoform is found in the ovary.DEVELOPMENTAL STAGE: Expressed in tissues undergoing reconstruction. Present in fetal tissues, especially in brain. Expression seems to decline with advanced development.
      DOMAIN: SwissProt: P51512 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
      PTM: The precursor is cleaved by a furin endopeptidase (By similarity).
      SIMILARITY: Belongs to the peptidase M10A family. & Contains 4 hemopexin-like domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Availability by Geography
      • This product is not available for sale in Japan.
      Usage Statement
      • Manufactured by Daiichi Fine Chemical Co., Ltd
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain frozen at -20°C in undiluted aliquots for up to 12 months.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      MAB3314 04053252663079

      Documentation

      Anti-MT3-MMP Antibody, Chemicon, purified mouse monoclonal, clone 117-10C6. SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Anti-MT3-MMP Antibody, Chemicon, purified mouse monoclonal, clone 117-10C6. Analysenzertifikate

      TitelChargennummer
      MOUSE ANTI-HUMAN- MT3-MMP 3170776
      MOUSE ANTI-HUMAN- MT3-MMP MONOCLONAL ANTIBODY - 2442557 2442557
      MOUSE ANTI-HUMAN- MT3-MMP - 3205432 3205432
      MOUSE ANTI-HUMAN- MT3-MMP - 3221939 3221939
      MOUSE ANTI-HUMAN- MT3-MMP -2567484 2567484
      MOUSE ANTI-HUMAN- MT3-MMP -2615122 2615122
      MOUSE ANTI-HUMAN- MT3-MMP -2641139 2641139
      MOUSE ANTI-HUMAN- MT3-MMP -2684250 2684250
      MOUSE ANTI-HUMAN- MT3-MMP -2691550 2691550
      MOUSE ANTI-HUMAN- MT3-MMP -2743589 2743589
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