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ABC835 Anti-SDHD Antibody

Detect SDHD using this Anti-SDHD Antibody validated for use in western blotting & ICC.

Anti-SDHD Antibody: SDB (Sicherheitsdatenblätter), Analysenzertifikate und Qualitätszertifikate, Dossiers, Broschüren und andere verfügbare Dokumente.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: SDHD, SD14 UniProt Number: O14521
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ABC835
100 µg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC835
      DescriptionAnti-SDHD Antibody
      Alternate Names
      • Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
      • CybS
      • CII-4
      • QPs3
      • Succinate dehydrogenase complex subunit D
      • Succinate-ubiquinone oxidoreductase cytochrome b small subunit
      • Succinate-ubiquinone reductase membrane anchor subunit
      Background InformationSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (CybS), also known as CII-4 or QPs3 or Succinate dehydrogenase complex subunit D or Succinate-ubiquinone oxidoreductase cytochrome b small subunit or Succinate-ubiquinone reductase membrane anchor subunit, and encoded by the gene name SDHD or SD14, is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumorsuppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect SDHD using this Anti-SDHD Antibody validated for use in western blotting & ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: 2.5 μg/mL from a representative lot detected Anti-SDHD in EL4 cells.
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to the center region of human Anti-SDHD.
      Epitopecenter region
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • SDHD
      • SD14
      Purification MethodAffinity
      UniProt Number
      Molecular Weight~16 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in EL4 cell lysate.

      Western Blotting Analysis: 2 μg/mL of this antibody detected Anti-SDHD in EL4 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      ABC835 04053252943935

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      Kategorien

      Life Science Research > Antibodies and Assays > Primary Antibodies