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219671 CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem

CFTR Inhibitor II, GlyH-101, CAS 328541-79-3, is a cell-permeable potent, selective and reversible open-channel blocker of CFTR (Ki = 4.3 µM in CFTR-expressing FRT cells).

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Synonyme: N-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide

Primary Target: CFTR
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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      328541-79-3C₁₉H₁₅Br₂N₃O₃
      Description
      OverviewA cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo. Also available as a 25 mM solution in DMSO (Cat. No. 219675).
      Catalogue Number219671
      Brand Family Calbiochem®
      SynonymsN-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide
      References
      ReferencesSonawane, N.D., et al. 2006. FASEB J. 20, 130.
      Muanprasat, C., et al. 2004. J. Gen. Physiol. 124, 125.
      Product Information
      CAS number328541-79-3
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₉H₁₅Br₂N₃O₃
      Chemical formulaC₁₉H₁₅Br₂N₃O₃
      HS Code2925 29 90
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCFTR
      Primary Target IC<sub>50</sub>95% inhibition at 50 µM
      Primary Target K<sub>i</sub>4.3 µM in CFTR-expressing FRT cells for apical membrane Cl- current
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      219671 0

      Documentation

      CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      CFTR Inhibitor II, GlyH-101 - CAS 328541-79-3 - Calbiochem Analysenzertifikate

      TitelChargennummer
      219671

      Literatur

      Übersicht
      Sonawane, N.D., et al. 2006. FASEB J. 20, 130.
      Muanprasat, C., et al. 2004. J. Gen. Physiol. 124, 125.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      SynonymsN-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide
      DescriptionA cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (< 1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo.
      FormYellow solid
      CAS number328541-79-3
      Chemical formulaC₁₉H₁₅Br₂N₃O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSonawane, N.D., et al. 2006. FASEB J. 20, 130.
      Muanprasat, C., et al. 2004. J. Gen. Physiol. 124, 125.