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233183 Clodronate, Disodium Salt - CAS 88416-50-6 - Calbiochem

A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption.

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Synonyme: Clodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate

Primary Target: Osteoclast-mediated bone resorption
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233183
Preis & Verfügbarkeit

Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
88416-50-6CH₂Cl₂O₆P₂Na₂ • 4H₂O

Preis & Verfügbarkeit

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233183-10MG
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      Description
      OverviewA non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. It is metabolized into a non-hydrolyzable ATP analog in osteoclasts and macrophages, and induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion, and migration of PC-3 prostate cancer cells (IC50 = 100 nM).
      Catalogue Number233183
      Brand Family Calbiochem®
      SynonymsClodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate
      References
      ReferencesLehenkari, P.P., et al. 2002. Mol. Pharmacol. 61, 1255.
      Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
      Smith, R., et al. 1971. Lancet 1, 945.
      Fleisch, H., et al. 1969. Nature 223, 211.
      Product Information
      CAS number88416-50-6
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaCH₂Cl₂O₆P₂Na₂ • 4H₂O
      Chemical formulaCH₂Cl₂O₆P₂Na₂ • 4H₂O
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetOsteoclast-mediated bone resorption
      Primary Target IC<sub>50</sub>100 nM inhibiting invasion, adhesion, and migration of PC-3 prostate cancer cells
      Purity≥97% by titration
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSSZ7640700
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      233183-10MG 04055977217773

      Documentation

      Clodronate, Disodium Salt - CAS 88416-50-6 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Clodronate, Disodium Salt - CAS 88416-50-6 - Calbiochem Analysenzertifikate

      TitelChargennummer
      233183

      Literatur

      Übersicht
      Lehenkari, P.P., et al. 2002. Mol. Pharmacol. 61, 1255.
      Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
      Smith, R., et al. 1971. Lancet 1, 945.
      Fleisch, H., et al. 1969. Nature 223, 211.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-April-2008 RFH
      SynonymsClodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate
      DescriptionA non-amino, chloro-containing, bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. Metabolized to a non-hydrolyzable ATP analog in osteoclasts and macrophages that induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion and migration of PC-3 prostate cancer cells (IC50 = 100 nM).
      FormWhite solid
      CAS number88416-50-6
      RTECSSZ7640700
      Chemical formulaCH₂Cl₂O₆P₂Na₂ • 4H₂O
      Structure formulaStructure formula
      Purity≥97% by titration
      SolubilityH₂O (1 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      Merck USA index14, 2371
      ReferencesLehenkari, P.P., et al. 2002. Mol. Pharmacol. 61, 1255.
      Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
      Smith, R., et al. 1971. Lancet 1, 945.
      Fleisch, H., et al. 1969. Nature 223, 211.