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538096 GluN2B NMDA Receptor Antagonist, 93-31 - CAS 457897-98-2 - Calbiochem

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Synonyme: (S)-N-(4-(3-(butyl(3,4-dichlorophenethyl)amino)-2-hydroxypropoxy)phenyl)methanesulfonamide

Primary Target: GluN2B NMDA Receptor
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538096
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Übersicht

Replacement Information

Key Spec Table

CAS #Empirical Formula
457897-98-2C₂₂H₃₀Cl₂N₂O₄S

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      Description
      OverviewA tertiary N-alkylamine that acts as a pH dependent antagonist of GluN2B-NMDA receptors. Shown to be about 10-fold more potent in ischemic tissue (pH 6.9) than in normal healthy tissue (pH 7.6) (IC50 = 190 nM and 1.8 µM, respectively). Effectively reduces the infarct volume in damaged brain tissue in a murine model of ischemic stroke (at 10 mg/kg, ED50 ≤ 1 mg/kg) without impairing coordination or motor function. Also displays binding to hERG (IC50 = 70 nM) and alpha1-adrenergic receptor (IC50 = 4.9 µM).
      Catalogue Number538096
      Brand Family Calbiochem®
      Synonyms(S)-N-(4-(3-(butyl(3,4-dichlorophenethyl)amino)-2-hydroxypropoxy)phenyl)methanesulfonamide
      References
      ReferencesYuan, H., et al. 2015. Neuron. 85, 1305.
      Tahirovic, Y., et al. 2008. J. Med. Chem. 51, 5506.
      Product Information
      CAS number457897-98-2
      FormLight yellow to yellow sticky solid
      Hill FormulaC₂₂H₃₀Cl₂N₂O₄S
      Chemical formulaC₂₂H₃₀Cl₂N₂O₄S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGluN2B NMDA Receptor
      Primary Target IC<sub>50</sub>0.19 µ
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      5380960001 04054839119521

      Documentation

      GluN2B NMDA Receptor Antagonist, 93-31 - CAS 457897-98-2 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Literatur

      Übersicht
      Yuan, H., et al. 2015. Neuron. 85, 1305.
      Tahirovic, Y., et al. 2008. J. Med. Chem. 51, 5506.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-July-2017 JSW
      Synonyms(S)-N-(4-(3-(butyl(3,4-dichlorophenethyl)amino)-2-hydroxypropoxy)phenyl)methanesulfonamide
      DescriptionA tertiary N-alkylamine that acts as a pH dependent antagonist of GluN2B-NMDA receptors. Shown to be about 10-fold more potent in ischemic tissue (pH 6.9) than in normal healthy tissue (pH 7.6) (IC50 = 190 nM and 1.8 µM, respectively). Effectively reduces the infarct volume in damaged brain tissue in a murine model of ischemic stroke (at 10 mg/kg, ED50 ≤ 1 mg/kg) without impairing coordination or motor function. Also displays binding to hERG (IC50 = 70 nM) and alpha1-adrenergic receptor (IC50 = 4.9 µM).
      FormLight yellow to yellow sticky solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number457897-98-2
      Chemical formulaC₂₂H₃₀Cl₂N₂O₄S
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesYuan, H., et al. 2015. Neuron. 85, 1305.
      Tahirovic, Y., et al. 2008. J. Med. Chem. 51, 5506.