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625625 Trehalose, Dihydrate - CAS 6138-23-4 - Calbiochem

Non-reducing disaccharide which yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro.

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Synonyme: 1-O-α-D-Glucopyranosyl-α-D-glucopyranoside

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      Übersicht

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      6138-23-4C₁₂H₂₂O₁₁ · 2H₂O
      Description
      OverviewNon-reducing disaccharide which yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro. Oral administration of trehalose has been shown to effectively extend lifespan in a murine Huntington disease model. Also known to accumulate in osmotically-stressed cultured bacterial cells and protect against the adverse effects of dehydration.
      Catalogue Number625625
      Brand Family Calbiochem®
      Synonyms1-O-α-D-Glucopyranosyl-α-D-glucopyranoside
      References
      ReferencesSarkar, S., et al. 2007. J. Biol. Chem. In press.
      Tanaka, M., et al. 2004. Nat. Med. 10, 148.
      Sastry, G.M. and Agmon, N. 1997. Biochemistry 36, 7097.
      Product Information
      CAS number6138-23-4
      FormSolid
      Hill FormulaC₁₂H₂₂O₁₁ · 2H₂O
      Chemical formulaC₁₂H₂₂O₁₁ · 2H₂O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97.5% by Assay
      Physicochemical Information
      ContaminantsHeavy metals: <10 ppm; iron: <5 ppm
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 24/25-37-45

      Avoid contact with skin and eyes.
      Wear suitable gloves.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Bestellnummer GTIN
      625625 0

      Documentation

      Trehalose, Dihydrate - CAS 6138-23-4 - Calbiochem SDB

      Titel

      Sicherheitsdatenblatt (SDB) 

      Trehalose, Dihydrate - CAS 6138-23-4 - Calbiochem Analysenzertifikate

      TitelChargennummer
      625625

      Literatur

      Übersicht
      Sarkar, S., et al. 2007. J. Biol. Chem. In press.
      Tanaka, M., et al. 2004. Nat. Med. 10, 148.
      Sastry, G.M. and Agmon, N. 1997. Biochemistry 36, 7097.
      Datenblatt

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-April-2010 JSW
      Synonyms1-O-α-D-Glucopyranosyl-α-D-glucopyranoside
      DescriptionNon-reducing disaccharide that yields 2 moles of D-glucose upon acid hydrolysis. Inhibits polyglutamine-mediated protein aggregation both in vivo and in vitro. Oral administration of trehalose has been shown to effectively extend lifespan in a murine Huntington disease model. Also known to accumulate in osmotically-stressed cultured bacterial cells and protect against the adverse effects of dehydration. Reported to prevent myoglobin collapse and preserve its internal mobility.
      FormSolid
      CAS number6138-23-4
      Chemical formulaC₁₂H₂₂O₁₁ · 2H₂O
      Structure formulaStructure formula
      Purity≥97.5% by Assay
      ContaminantsHeavy metals: <10 ppm; iron: <5 ppm
      SolubilityH₂O (100 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Toxicity Standard Handling
      Merck USA index14, 9580
      ReferencesSarkar, S., et al. 2007. J. Biol. Chem. In press.
      Tanaka, M., et al. 2004. Nat. Med. 10, 148.
      Sastry, G.M. and Agmon, N. 1997. Biochemistry 36, 7097.