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MABN1571 Anti-ARHGEF9 Antibody, clone 4D7.1

Anti-ARHGEF9 Antibody, clone 4D7.1, Cat. No. MABN1571, is a highly specific mouse monoclonal antibody that targets ARHGEF9 and has been tested in Western Blotting.

Anti-ARHGEF9 Antibody, clone 4D7.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: ARHGEF9, ARHDH9, EIEE8, KIAA0424 UniProt Number: O43307
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MABN1571
100 µL  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN1571
      DescriptionAnti-ARHGEF9 Antibody, clone 4D7.1
      Alternate Names
      • Rho guanine nucleotide exchange factor 9
      • Collybistin
      • PEM-2 homolog
      • Rac/Cdc42 guanine nucleotide exchange factor 9
      Background InformationRho guanine nucleotide exchange factor 9 (UniProt O43307; also known as Collybistin, PEM-2 homolog, Rac/Cdc42 guanine nucleotide exchange factor 9) is encoded by the ARHGEF9 (also known as ARHDH9, EIEE8, KIAA0424) gene (Gene ID 23229) in human. Guanine nucleotide exchange factors (GEFs) are cytoplasmic proteins that activate GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP). ARHGEF9 acts as a specific GEF for CDC42 and promotes formation of GPHN clusters. In the brain tissue it interacts with the receptor-anchoring protein gephyrin to activate dc42, which is known to regulate actin cytoskeleton dynamics. Its binding to gephyrin can also modulate GABAergic and glycinergic neurotransmission at the synapse. Abnormalities in its expression have been linked to epileptic encephalopathy, early infantile, 8.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide
      Quality LevelMQ100
      Applications
      ApplicationAnti-ARHGEF9 Antibody, clone 4D7.1, Cat. No. MABN1571, is a highly specific mouse monoclonal antibody that targets ARHGEF9 and has been tested in Western Blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: A 1:500 dilution from a representative lot detected ARHGEF9 in 10 µg of mouse whole brain tissue lysate.
      Biological Information
      ImmunogenGST-tagged human ARHGEF9 C-terminal fragment.
      Clone4D7.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 4D7.1 targets ARHGEF9 C-terminal region present in human isoforms 1/2/3 and mouse isoforms 1/2/4 reported by UniProt (O43307 and Q3UTH8). Reactivity toward mouse isoform 3 is not expected.
      IsotypeIgG2bκ
      Species Reactivity
      • Mouse
      Species Reactivity NoteMouse. Predicted to react with Human based on 100% sequence homology.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ARHGEF9
      • ARHDH9
      • EIEE8
      • KIAA0424
      Purification MethodProtein G purified.
      UniProt Number
      Molecular Weight~61 kDa observed. 60.98/54.97/49.46 kDa (human isoform 1/2/3) and 60.93/58.62/60.86 kDa (mouse isoform 1/2/4) calculated. Human isoforms 1 and 2 are also known as CB3(SH3+) and CB3(SH3-). Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse hypothalamus tissue lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected ARHGEF9 in 10 µg of mouse hypothalamus tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABN1571 04054839092015