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MABS1242 Anti-CYP2J2 Antibody, clone 6-5-20-8

Anti-CYP2J2, clone 6-5-20-8, Cat. No. MABS1242, is a mouse monoclonal antibody that targets cytochrome P450 2J2 and is tested for use in Inhibition Assay and Western Blotting.

Anti-CYP2J2 Antibody, clone 6-5-20-8 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Gene Symbol: CYP2J2 UniProt Number: P51589
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MABS1242
100 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, HWB, InhibitionMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS1242
      DescriptionAnti-CYP2J2 Antibody, clone 6-5-20-8
      Alternate Names
      • Cytochrome P450 2J2
      • Arachidonic acid epoxygenase
      • CYPIIJ2
      Background InformationCytochrome P450 2J2 (UniProt: P51589; also known as EC:1.14.14.1, Arachidonic acid epoxygenase, CYPIIJ2) is encoded by the CYP2J2 gene (Gene ID: 1573) in human. Cytochrome P450 2J2 is an endoplasmic reticulum microsomal enzyme that metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. It is responsible for the epoxidation of endogenous cardiac arachidonic acid pools. It is highly expressed in heart and is present at lower levels in liver, ileum, jejunum, colon, and kidney. It is reported to activate the nuclear peroxisome proliferator-activated receptor alpha (PPAR alpha) and hence plays a role in lipid metabolism and inflammation. Overexpression of CYP2J2 in vivo is shown to reverse several pathological processes in animals, including hypertension, other cardiovascular pathologies, and insulin resistance.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in PBS without azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-CYP2J2, clone 6-5-20-8, Cat. No. MABS1242, is a mouse monoclonal antibody that targets cytochrome P450 2J2 and is tested for use in Inhibition Assay and Western Blotting.
      Key Applications
      • Western Blotting
      • Inhibition
      Application NotesInhibition Analysis: A representative lot detected CYP2J2 in Inhibition applications (Xiao, Y.F., et. al. (2004). Mol Pharmacol. 66(6):1607-16).

      Western Blotting Analysis: A representative lot detected CYP2J2 in Western Blotting applications (Xiao, Y.F., et. al. (2004). Mol Pharmacol. 66(6):1607-16).
      Biological Information
      ImmunogenA full-length recombinant human cytochrome P450 2J2.
      Clone6-5-20-8
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 6-5-20-8 detects cytochrome p450 2J2 in human and murine species.
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      • Human
      Species Reactivity NoteHuman, Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CYP2J2
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~52 kDa observed; 57.61 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse heart tissue lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected CYP2J2 in 20 µg of mouse heart tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABS1242 04054839204098