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MAB10139 Anti-LIM Domain Only 2 Antibody, clone 2E6

Detect LIM Domain Only 2 using this Anti-LIM Domain Only 2 Antibody, clone 2E6 validated for use in WB.

Anti-LIM Domain Only 2 Antibody, clone 2E6 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Developmental Signaling Gene Symbol: LMO2, RHOM2, TTG2, RBTN2, Rhombotin-2, RBTNL1 UniProt Number: P25791
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MAB10139
100 µL  
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      Overview

      Replacement Information

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMCulture SupernatantMonoclonal Antibody
      Description
      Catalogue NumberMAB10139
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-LIM Domain Only 2 Antibody, clone 2E6
      Background InformationLIM Domain only 2 (LMO2) encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur.
      References
      Product Information
      FormatCulture Supernatant
      PresentationLiquid containing 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect LIM Domain Only 2 using this Anti-LIM Domain Only 2 Antibody, clone 2E6 validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenRecombinant human LMO2
      Clone2E6
      HostMouse
      SpecificityHuman
      IsotypeIgG2a
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryLMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur.
      Gene Symbol
      • LMO2
      • RHOM2
      • TTG2
      • RBTN2
      • Rhombotin-2
      • RBTNL1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P25791 # Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.
      SIZE: 158 amino acids; 18358 Da
      SUBUNIT: Interacts via its LIM domains with ELF2 and LBD1. Also interacts with basic helix-loop-helix protein TAL1/SCL and can assemble in a complex with LMO2 and TAL1/SCL (By similarity). Interacts with BEX2 and JARID1A.
      SUBCELLULAR LOCATION: Nucleus (Potential).
      DOMAIN: SwissProt: P25791 The second LIM zinc-binding domain interacts with JARID1A.
      DISEASE:SwissProt: P25791 # A chromosomal aberration involving LMO2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p13;q11) with TCRD.
      SIMILARITY: Contains 2 LIM zinc-binding domains.
      Molecular Weight18kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at 4°C from date of shipment
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MAB10139 04053252466410

      Documentation

      Anti-LIM Domain Only 2 Antibody, clone 2E6 SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overviewPub Med ID
      The significance of LMO2 expression in the progression of prostate cancer
      Ma, S, et al
      J Pathol, 211:278-85 (2007)  2007

      		17167821 17167821
      The oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B-cell lymphomas
      Natkunam, Yasodha, et al
      Blood, 109:1636-42 (2007)  2007

      		17038524 17038524

      Data Sheet

      Title
      MOUSE ANTI-LIM DOMAIN ONLY 2 MONOCLONAL ANTIBODY