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SCT278-3X100NMOL BioTracker™ Far Red Mitochondrial Superoxide Live Cell Probe

BioTracker Far Red Mitochondrial Superoxide Live Cell Probe selectively detects superoxide. and is sensitive enough for small samples. SCT278 fluoresces in a longer wavelength to enhance understanding of how mitochondria are altered during diverse physi

SCT278-3X100NMOL
300 nmol  
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCT278-3X100NMOL
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      DescriptionBioTracker™ Far Red Mitochondrial Superoxide Live Cell Probe
      OverviewThe BioTracker™ Far Red Mitochondrial Superoxide Live Cell Probe detects superoxide, a reactive oxygen species (ROS) produced in mitochondria by electrons leaking during redox reactions. Cellular control of ROS is important because they are associated with disease, cellular damage and senescence. SCT278 is oxidized by mitochondrial superoxide and accumulated in mitochondria.

      The BioTracker™ Far Red Mitochondrial Superoxide Live Cell Probe SCT278
      *enables detection of mitochondrial superoxide with a long wavelength (far red)
      *permits co-staining with green or red fluorescent probes
      *demonstrates high selectivity for superoxide

      SPECTRAL PROPERTIES:
      Ex 540 nm
      Em 670 nm

      Add 10 μL of DMSO to each tube containing SCT278 (100 nmol) to create a 10 mM stock solution. Dilute stock solution with culture medium to create a 10 uM working solution.
      Alternate Names
      • mitochondrial superoxide probe
      Background InformationMitochondria are important organelles that uses oxygen to synthesize ATP, producing the necessary energy for living cells to thrive. Increased mitochondrial activity and mitochondrial dysfunction are associated with cancer, aging, and neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Mitochondrial mass (MM), mitochondrial membrane potential (MMP), and mitochondrial ROS (mtROS) have been widely studied as promising targets for mitochondria-related diseases. Since these mitochondrial attributes are dynamic, simultaneous analysis using multiple staining in a single sample is required.

      Other red fluorescent reagents have widely been used to detect mitochondrial superoxide. However, their emission wavelength is a shorter red, which overlaps with other membrane potential detection probes such as TMRE, and is therefore not applicable for simultaneous staining with other mitochondrial markers in a multiplexed sample.
      References
      Product Information
      FormatLyophilized solid
      PresentationWhite to pale purple solid
      Applications
      ApplicationBioTracker Far Red Mitochondrial Superoxide Live Cell Probe selectively detects superoxide. and is sensitive enough for small samples. SCT278 fluoresces in a longer wavelength to enhance understanding of how mitochondria are altered during diverse physi
      Key Applications
      • Cell Based Assays
      • Fluorescence
      • Flow Cytometry
      • Fluorescence Activated Cell Sorting (FACS)
      Application NotesLive cell probe for the detection of mitochondrial superoxide, which can alter mitochondrial membrane permeability to promote apoptosis.
      Biological Information
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at 2 - 8 °C, protected from light.
      Packaging Information
      Material Size300 nmol
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCT278-3X100NMOL 0

      Documentation

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