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205530 CA-074 - Calbiochem

CA-074, also referenced under CAS 134448-10-5, modulates the biological activity of cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

CA-074 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Cathepsin B Inhibitor III, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline

Primary Target: cathepsin B
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₈H₂₉N₃O₆
      Description
      OverviewAn epoxysuccinyl peptide that acts as a potent, irreversible, and specific inhibitor of cathepsin B (IC50 = 2.24 nM for rat liver cathepsin B). Reduces ischemia-induced neuronal death. Exhibits lower membrane permeability when compared to CA-074 Me (Cat. No. 205531).
      Catalogue Number205530
      Brand Family Calbiochem®
      SynonymsCathepsin B Inhibitor III, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline
      References
      ReferencesChan, V.J., et al. 1999. Biochem. J. 340, 113.
      Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187.
      Yamamoto, A., et al. 1997. J. Biochem. 121, 974.
      Inubushi, T., et al. 1994. J. Biochem. 116, 282.
      Murata, M., et al. 1991. FEBS Lett. 280, 307.
      Towatari, T., et al. 1991. FEBS Lett. 280, 311.
      Product Information
      ATP CompetitiveN
      FormColorless or white solid
      Hill FormulaC₁₈H₂₉N₃O₆
      Chemical formulaC₁₈H₂₉N₃O₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcathepsin B
      Primary Target IC<sub>50</sub>2.24 nM for rat liver cathepsin B
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      205530 0

      Documentation

      CA-074 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      CA-074 - Calbiochem Certificates of Analysis

      TitleLot Number
      205530

      References

      Reference overview
      Chan, V.J., et al. 1999. Biochem. J. 340, 113.
      Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187.
      Yamamoto, A., et al. 1997. J. Biochem. 121, 974.
      Inubushi, T., et al. 1994. J. Biochem. 116, 282.
      Murata, M., et al. 1991. FEBS Lett. 280, 307.
      Towatari, T., et al. 1991. FEBS Lett. 280, 311.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-May-2008 RFH
      SynonymsCathepsin B Inhibitor III, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline
      DescriptionA potent, irreversible inhibitor of Cathepsin B in vivo and in vitro (IC50 = 2.24 nM for rat liver cathepsin B).
      FormColorless or white solid
      Chemical formulaC₁₈H₂₉N₃O₆
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesChan, V.J., et al. 1999. Biochem. J. 340, 113.
      Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187.
      Yamamoto, A., et al. 1997. J. Biochem. 121, 974.
      Inubushi, T., et al. 1994. J. Biochem. 116, 282.
      Murata, M., et al. 1991. FEBS Lett. 280, 307.
      Towatari, T., et al. 1991. FEBS Lett. 280, 311.