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218773 Caspase-8 Inhibitor I, Cell-Permeable - Calbiochem

Caspase-8 Inhibitor I, Cell-Permeable, is a potent, reversible inhibitor of caspase-8 and Granzyme B.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Granzyme B Inhibitor II, Cell-permeable, IETD-CHO, Cell-permeable

Primary Target: caspase-8
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₉₅H₁₆₂N₂₀O₂₆
      Description
      OverviewA potent, cell-permeable, and reversible inhibitor of caspase-8 and Granzyme B. The N-terminal sequence (amino acids 1-16) corresponds to the hydrophobic region of the signal peptide of Kaposi fibroblast growth factor and confers cell permeability to the peptide.
      Catalogue Number218773
      Brand Family Calbiochem®
      SynonymsGranzyme B Inhibitor II, Cell-permeable, IETD-CHO, Cell-permeable
      References
      ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Hamada, E., et al. 1990. J. Hepatol. 30, 807.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      Hill FormulaC₉₅H₁₆₂N₂₀O₂₆
      Chemical formulaC₉₅H₁₆₂N₂₀O₂₆
      ReversibleY
      Quality LevelMQ100
      Applications
      ApplicationCaspase-8 Inhibitor I, Cell-Permeable, is a potent, reversible inhibitor of caspase-8 and Granzyme B.
      Biological Information
      Primary Targetcaspase-8
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      218773 0

      Documentation

      Caspase-8 Inhibitor I, Cell-Permeable - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Caspase-8 Inhibitor I, Cell-Permeable - Calbiochem Certificates of Analysis

      TitleLot Number
      218773

      References

      Reference overview
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Hamada, E., et al. 1990. J. Hepatol. 30, 807.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-June-2008 RFH
      SynonymsGranzyme B Inhibitor II, Cell-permeable, IETD-CHO, Cell-permeable
      DescriptionPotent, cell-permeable and reversible inhibitor of caspase-8 and Granzyme B.
      FormWhite lyophilized solid
      Chemical formulaC₉₅H₁₆₂N₂₀O₂₆
      Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Ile-Glu-Thr-Asp-CHO
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Hamada, E., et al. 1990. J. Hepatol. 30, 807.