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852008 Fmoc-Cys(Trt)-OH

Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
103213-32-7C₇H₃₁NO₄S585.73 g/mol

Pricing & Availability

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8520080025
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      8520080100
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          8520080250
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                  8520081000
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                      8520085000
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                          Description
                          Catalogue Number852008
                          Replaces04-12-1018
                          Brand Family Novabiochem®
                          Alternate Names
                          • N-α-Fmoc-S-trityl-L-cysteine
                          Background InformationThe standard derivative for Fmoc SPPS of peptides containing Cys [1]. The Trt group is removed with 95% TFA containing 1-5% TIS. Ideally, this derivative should be introduced using the symmetrical anhydride or DIPCDI/HOBt activation [2,3] to minimize enantiomerization. If activation with uronium or phosphonium reagents, such as HBTU or PyBOP®, is to be employed, it is strongly recommended that collidine is used as the base [4], as this has been shown to significantly reduce loss of optical integrity during coupling.

                          The product number for this product was previously 04-12-1018.

                          To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
                          References
                          Product Information
                          CAS number103213-32-7
                          Hill FormulaC₇H₃₁NO₄S
                          Molar Mass585.73 g/mol
                          HS Code2930 90 19
                          Structure formula ImageStructure formula Image
                          Quality LevelMQ400
                          Applications
                          ApplicationFmoc-Cys(Trt)-OH Novabiochem®. CAS 103213-32-7, molar mass 585.72 g/mol.
                          Biological Information
                          Physicochemical Information
                          Melting Point164 - 175 °C
                          Dimensions
                          Materials Information
                          Toxicological Information
                          Safety Information according to GHS
                          Storage class10 - 13 Other liquids and solids
                          WGKWGK 3 highly hazardous to water
                          Safety Information
                          Product Usage Statements
                          Storage and Shipping Information
                          StorageStore at -15°C to -25°C.
                          Packaging Information
                          Transport Information
                          Supplemental Information
                          Specifications
                          Color (visual)white to off white
                          Appearance of substance (visual)powder
                          Color index (0,5 M in DMF)≤ 150 Hazen
                          Identity (IR)passes test
                          Enantiomeric purity≥ 99.5 % (a/a)
                          Purity (HPLC)≥ 99.0 % (a/a)
                          Fmoc-ß-Ala-OH (HPLC)≤ 0.1 % (a/a)
                          Fmoc-ß-Ala-Cys (Trt) -OH (HPLC)≤ 0.1 % (a/a)
                          Fmoc-Cys(Trt)-Cys(Trt)-OH (HPLC)≤ 0.1 % (a/a)
                          Fmoc-Cys-OH (HPLC)≤ 0.1 % (a/a)
                          Assay free amino acid (HPLC)≤ 0.2 %
                          Purity (TLC(011A))≥ 98 %
                          Purity (TLC(0811))≥ 98 %
                          Solubility (1 mmole in 2 ml DMF)clearly soluble
                          Assay (acidimetric)≥ 98.0 %
                          Water (K. F.)≤ 2.0 %
                          Ethyl acetate (HS-GC)≤ 0.5 %
                          Acetate (IC)≤ 0.02 %
                          For TLC-Systems see our General Catalog
                          Global Trade Item Number
                          Catalogue Number GTIN
                          8520080025 04027269084783
                          8520080100 04027269084790
                          8520080250 04027269206932
                          8520080500 04027269179182
                          8520081000 04027269179199
                          8520085000 04027269221485

                          Documentation

                          Fmoc-Cys(Trt)-OH SDS

                          Title

                          Safety Data Sheet (SDS) 

                          Citations

                          Title
                          • [1] S. N. McCurdy (1989) Pept. Res., 2, 147.
                          • [2] T. Kaiser, et al. (1996) Tetrahedron Lett., 37, 1187.
                          • [3] Y. X. Han, et al. (1997) J. Org. Chem., 62, 4307.
                          • [4] Y. N. Angell (2002) J. Peptide Res., 5, 292.