Millipore Sigma Vibrant Logo

855029 N-Cyclohexylcarbodiimide,N'-methyl polystyrene

Novabiochem®

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 9003-70-7
View Products on Sigmaaldrich.com
855029
View Pricing & Availability

Overview

Replacement Information

Key Spec Table

CAS #
9003-70-7

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
8550290005
Retrieving availability...
—
Fulfillment and delivery delayed Fulfillment and delivery delayed
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Plastic bottle 5 g
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      8550290025
      Retrieving availability...
      —
      Fulfillment and delivery delayed Fulfillment and delivery delayed
      In Stock 
      Discontinued
      Limited Quantities Available
      Availability to be confirmed
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          		 Plastic bottle 25 g
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity is a multiple of
          Maximum Quantity is
          Upon Order Completion More Information
          You Saved ()
           
          —
          Request Pricing
          		 —
          8550290100
          Retrieving availability...
          —
          Fulfillment and delivery delayed Fulfillment and delivery delayed
          In Stock 
          Discontinued
          Limited Quantities Available
          Availability to be confirmed
            Remaining : Will advise
              Remaining : Will advise
              Will advise
              Contact Customer Service
              Contact Customer Service

              		 Plastic bottle 100 g
              Retrieving price...
              Price could not be retrieved
              Minimum Quantity is a multiple of
              Maximum Quantity is
              Upon Order Completion More Information
              You Saved ()
               
              —
              Request Pricing
              		 —
              Description
              Catalogue Number855029
              Replaces01-64-0211
              Brand Family Novabiochem®
              Background InformationN-Cyclohexylcarbodiimide,N'-methyl polystyrene [1] is an ideal tool for mediating solution phase coupling reactions. Typically, the amine and carboxylic acid are treated with a 2-3 fold excess of resin in DCM or DMF [2, 3]; a slight excess of carboxyl component over amine component is often used to help drive the reaction to completion. As excess acid and urea by-products remain attached to the resin at the end of the reaction, the product can normally be isolated pure by filtration and evaporation of the reaction mixture. Reactions can be accelerated by the addition of auxiliary nucleophiles such as HOBt; these can be removed using polyamine- or TBD-polystyrene. This resin has also been used in conjunction with DMAP to mediate ester formation [4].

              The product number for this product was previously 01-64-0211.

              To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
              References
              Product Information
              CAS number9003-70-7
              HS Code3903 90 90
              Structure formula ImageStructure formula Image
              Quality LevelMQ200
              Applications
              Biological Information
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Storage class10 - 13 Other liquids and solids
              WGKWGK 1 slightly hazardous to water
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              StorageStore at +2°C to +8°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Color (visual)slightly beige to brown
              Appearance of substance (visual)beads
              Loading (determined by HPLC after reaction of Z-Phe-OH with cyclohexylamine)≥ 1.3 mmol/g
              Swelling Volume (in CH₂Cl₂)lot specific result
              The polymer matrix is copoly (styrene-2 % DVB), 200 - 400 mesh.
              Global Trade Item Number
              Catalogue Number GTIN
              8550290005 04027269110475
              8550290025 04027269110482
              8550290100 04027269110499

              Documentation

              N-Cyclohexylcarbodiimide,N'-methyl polystyrene SDS

              Title

              Safety Data Sheet (SDS) 

              Citations

              Title
              • [1] G.M Weinshenker, et al. (1988) Org. Synth., Coll. Vol. VI, 951.
              • [2] Y. Guan, et al. (2000) J. Comb. Chem., 2, 297.
              • [3] K. Senton, et al. (2003) J. Comb. Chem., 5, 336.
              • [4] M. Cano, et al. (2002) J. Org. Chem., 67, 129.