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855010 NovaSyn®TGT alcohol resin

Novabiochem®

NovaSyn®TGT alcohol resin MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 478242-36-3
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855010
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Overview

Replacement Information

Key Spec Table

CAS #
478242-36-3

Pricing & Availability

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8550100001
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      		 Glass bottle 1 g
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      8550100005
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          		 Plastic bottle 5 g
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          8550100025
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              		 Plastic bottle 25 g
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              Description
              Catalogue Number855010
              Replaces01-64-0066
              Brand Family Novabiochem®
              Background InformationNovaSyn® TGT alcohol resin is derived from TG amino resin by acylation with Bayer's 4-carboxytrityl linker [1]. Before use the resin must be converted to the chloride form by heating with AcCl [2, 3] or SOCl2 [4, 5] in toluene. The unstable trityl chloride resin should then be used immediately.

              Attachment of α-amino acids is free from enantiomerization, making this support ideal for the immobilization of sensitive residues such as Cys and His.

              Iodine oxidation of peptides containing Cys(Trt) occurs with release of the peptide from the resin.

              This support is also ideally suited to the synthesis of prolyl peptides as the bulk of the trityl handle prohibits diketopiperazine formation [6].

              Cleavage of protected peptide acids from this matrix can be effected by treatment with AcOH/MeOH/DCM [1], 0.5% TFA or HFIP [7].

              The product number for this product was previously 01-64-0066.

              To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
              References
              Product Information
              CAS number478242-36-3
              HS Code3903 90 90
              Structure formula ImageStructure formula Image
              Quality LevelMQ200
              Applications
              Biological Information
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Storage class10 - 13 Other liquids and solids
              WGKWGK 1 slightly hazardous to water
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              StorageStore at +2°C to +8°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Color (visual)white to yellow to beige
              Appearance of substance (visual)beads
              Loading (determined from the substitution of the Fmoc-Leu loaded resin)0.15 - 0.30 mmol/g
              Swelling Volume (in CH₂Cl₂)lot specific result
              The polymer matrix is NovaSyn TG resin (90 µm).
              Global Trade Item Number
              Catalogue Number GTIN
              8550100001 04027269109547
              8550100005 04027269109554
              8550100025 04027269109561

              Documentation

              NovaSyn®TGT alcohol resin SDS

              Title

              Safety Data Sheet (SDS) 

              Citations

              Title
              • [1] E. Bayer, et al. in 'Peptides, Chemistry, Structure & Biology, Proc. 13th American Peptide Symposium', R. S. Hodges & J. A. Smith (Eds), ESCOM, Leiden, 1994, pp. 156.
              • [2] J. M. J. Frechet, et al. (1975) Tetrahedron Lett., 3055.
              • [3] T. M. Fyles, et al. (1976) Can. J. Chem., 54, 935.
              • [4] A. v. Vliet, et al. in 'Innovation & Perspectives in Solid Phase Synthesis, 2nd International Symposium', R. Epton (Eds), Intercept UK Ltd., Andover, 1992, pp. 475.
              • [5] A. v. Vliet, et al. in 'Peptides 1992, Proc. 22nd European Peptide Symposium', C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden, 1993, pp. 279.
              • [6] G. Grübler, et al. in 'Innovation & Perspectives in Solid Phase Synthesis, 3rd International Symposium', R. Epton (Eds), Mayflower Worldwide Ltd., Birmingham, 1994, pp. 517.
              • [7] R. Bollhagen, et al. (1994) J. Chem. Soc., Chem. Commun., 2559.