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557330 Rolipram - CAS 61413-54-5 - Calbiochem

A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC₅₀ = 800 nM).

Rolipram - CAS 61413-54-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone

Primary Target: PDE IV
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557330
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
61413-54-5C₁₆H₂₁NO₃

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557330-5MG
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      Description
      OverviewA cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50 = 800 nM). A rolipram-insensitive PDE IV subtype is also known to exist. Also inhibits NF-κB and NFAT activation in Jurkat and primary T cells.
      Catalogue Number557330
      Brand Family Calbiochem®
      Synonyms4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
      References
      ReferencesNavarro, J., et al. 1998. J. Virol. 72, 4712.
      Truong, V.H. and Muller, T. 1994. FEBS Lett. 353, 113.
      Underwood, D.C., et al. 1994. J. Pharmacol. Exp. Ther. 270, 250.
      Moore, J.B., Jr., et al. 1991. Biochem. Pharmacol. 42, 679.
      Reeves, M.L., et al. 1987. Biochem. J. 241, 535.
      Schneider, H.H., et al. 1986. Eur. J. Pharmacol. 127, 105.
      Product Information
      CAS number61413-54-5
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₆H₂₁NO₃
      Chemical formulaC₁₆H₂₁NO₃
      HS Code2933 79 90
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPDE IV
      Primary Target IC<sub>50</sub>800 nM against cAMP-specific phosphodiesterase (PDE IV)
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUY5749237
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      557330-5MG 04055977267945

      Documentation

      Rolipram - CAS 61413-54-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Rolipram - CAS 61413-54-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      557330

      References

      Reference overview
      Navarro, J., et al. 1998. J. Virol. 72, 4712.
      Truong, V.H. and Muller, T. 1994. FEBS Lett. 353, 113.
      Underwood, D.C., et al. 1994. J. Pharmacol. Exp. Ther. 270, 250.
      Moore, J.B., Jr., et al. 1991. Biochem. Pharmacol. 42, 679.
      Reeves, M.L., et al. 1987. Biochem. J. 241, 535.
      Schneider, H.H., et al. 1986. Eur. J. Pharmacol. 127, 105.

      Brochure

      Title
      Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-June-2008 JSW
      Synonyms4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
      DescriptionCell permeable, selective competitive inhibitor of cAMP-specific phosphodiesterase IV (IC50 = 800 nM). Rolipram does not inhibit PDE I or PDE II, even at concentrations as high as 100 µM. It is only a weak inhibitor of PDE III (IC50 = 100 µM). A rolipram-insensitive phosphodiesterase IV subtype is also known to exist.
      FormWhite solid
      CAS number61413-54-5
      RTECSUY5749237
      Chemical formulaC₁₆H₂₁NO₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      Merck USA index14, 8251
      ReferencesNavarro, J., et al. 1998. J. Virol. 72, 4712.
      Truong, V.H. and Muller, T. 1994. FEBS Lett. 353, 113.
      Underwood, D.C., et al. 1994. J. Pharmacol. Exp. Ther. 270, 250.
      Moore, J.B., Jr., et al. 1991. Biochem. Pharmacol. 42, 679.
      Reeves, M.L., et al. 1987. Biochem. J. 241, 535.
      Schneider, H.H., et al. 1986. Eur. J. Pharmacol. 127, 105.