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200487 β-Amyloid Oligomer Inhibitor, K01-162 - Calbiochem

200487
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Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₁₅H₁₄BrN

Prix & Disponibilité

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200487-10MG
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      Description
      OverviewA cell permeable, fluorene compound that destabilizes the aggregation state of β-amyloid oligomers (AβO) by directly targeting AβO and inhibiting AβO binding to synapses. It displays full MC65 protection at 125 nM, with an EC50 of 80 nM in a neuronal MC65 culture-based assay, and substantially reduces intraneuronal AβO in primary neuronal culture at concentrations between 100 nM and 10 µM. Furthermore, it is shown to significantly reduce amyloid levels by 50% compared with control in vivo in a 5xFAD mice cerebral Aβ amyloidosis model when dosed intracerebroventricularly without apparent toxicity.
      Catalogue Number200487
      Brand Family Calbiochem®
      SynonymsAβO Inhibitor, K01-162
      References
      ReferencesHong, H-S., et al. 2010. Neurobiol. Aging 31, 1690.
      Product Information
      FormWhite to off-white solid
      Hill FormulaC₁₅H₁₄BrN
      Chemical formulaC₁₅H₁₄BrN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      β-Amyloid Oligomer Inhibitor, K01-162 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      β-Amyloid Oligomer Inhibitor, K01-162 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      200487

      Références bibliographiques

      Aperçu de la référence bibliographique
      Hong, H-S., et al. 2010. Neurobiol. Aging 31, 1690.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-March-2018 JSW
      SynonymsAβO Inhibitor, K01-162
      DescriptionA cell permeable, fluorene compound that destabilizes the aggregation state of β-amyloid oligomers (AβO) by directly targeting AβO and inhibiting AβO binding to synapses. It displays full MC65 protection at 125 nM, with an EC50 of 80 nM in a neuronal MC65 culture-based assay, and substantially reduces intraneuronal AβO in primary neuronal culture at concentrations between 100 nM and 10 µM. Furthermore, it is shown to significantly reduce amyloid levels by 50% compared with control in vivo in a 5xFAD mice cerebral Aβ amyloidosis model when dosed intracerebroventricularly without apparent toxicity.
      FormWhite to off-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₅H₁₄BrN
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHong, H-S., et al. 2010. Neurobiol. Aging 31, 1690.