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203391 (-)-Blebbistatin - CAS 856925-71-8 - Calbiochem

203391
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Empirical FormulaCAS #
C₁₈H₁₆N₂O₂ 856925-71-8

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203391-1MG
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      Description
      OverviewThe active enantiomer of (±)-Blebbistatin (Cat. No. 203390) that accounts for the inhibitory activity towards ATPase (IC50 = ~2 µM) and myosin II-dependent cellular processes. Also reported to potently inhibit the actomyosin ATPase activities of expressed smooth muscle myosin IIA (SMA) and smooth muscle myosin IIB (SMB) smooth muscle myosin II heavy-chain isoforms (IC50 ~3 µM).
      Catalogue Number203391
      Brand Family Calbiochem®
      References
      ReferencesEddinger, T.J. et al. 2007. J. Pharmacol. Exp. Ther. 320, 865.
      Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
      Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
      Straight, A.F., et al. 2003. Science 299, 1743.
      Product Information
      CAS number856925-71-8
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₈H₁₆N₂O₂
      Chemical formulaC₁₈H₁₆N₂O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetATPase
      Primary Target IC<sub>50</sub>2 µM
      Purity≥98% by Chiral HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month in 90% DMSO or methanol (-20°C). Stock solutions in 100% DMSO are unstable; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      (-)-Blebbistatin - CAS 856925-71-8 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      (-)-Blebbistatin - CAS 856925-71-8 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      203391

      Références bibliographiques

      Aperçu de la référence bibliographique
      Eddinger, T.J. et al. 2007. J. Pharmacol. Exp. Ther. 320, 865.
      Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
      Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
      Straight, A.F., et al. 2003. Science 299, 1743.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-March-2011 RFH
      DescriptionThe active enantiomer of (±)-Blebbistatin (Cat. No. 203390) that accounts for the inhibitory activity toward ATPase (IC50 ~2 µM) and myosin II-dependent cellular processes. Also reported to potently inhibit the actomyosin ATPase activities of expressed smooth muscle myosin IIA (SMA) and smooth muscle myosin IIB (SMB) smooth muscle myosin II heavy-chain isoforms (IC50 ~3 µM).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number856925-71-8
      Chemical formulaC₁₈H₁₆N₂O₂
      Structure formulaStructure formula
      Purity≥98% by Chiral HPLC
      Solubility100% DMSO (100 mg/ml), 90% DMSO (75 mg/ml) or Methanol (1.5 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month in 90% DMSO or methanol (-20°C). Stock solutions in 100% DMSO are unstable; reconstitute just prior to use.
      Toxicity Harmful & Carcinogenic / Teratogenic
      ReferencesEddinger, T.J. et al. 2007. J. Pharmacol. Exp. Ther. 320, 865.
      Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
      Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
      Straight, A.F., et al. 2003. Science 299, 1743.