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219334 β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem

The β-Catenin/Tcf Inhibitor V, BC21, also referenced under CAS 691005-38-6, controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Biochemicals applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Copper, di-µ-chlorobis[1-[(1-piperidinyl-κN)methyl]-2-naphthalenolato-κO]di-(9Cl), Wnt Pathway Inhibitor XV

219334
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Tableau de caractéristiques principal

CAS #Empirical Formula
691005-38-6C₃₂H₃₆Cl₂Cu₂N₂O₂

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      Description
      OverviewA cell-permeable dimeric copper complex that competitively binds β-catenin and disrupts β-catenin/Tcf4 interaction reversibly (IC50 = 5.0 µM), and acts as a Wnt signaling inhibitor. Shown to induce preferential growth arrest in β-catenin overexpressing HCT116 colon cancer and HEK293 cells (≤ 10 µM), and downregulate mRNA expressions of c-Myc and cyclin D1. Reported to inhibit PP2C and proteasomal activities at higher concentrations (~50 µM).
      Catalogue Number219334
      Brand Family Calbiochem®
      SynonymsCopper, di-µ-chlorobis[1-[(1-piperidinyl-κN)methyl]-2-naphthalenolato-κO]di-(9Cl), Wnt Pathway Inhibitor XV
      References
      ReferencesTian, W., et al. 2012. Biochemistry 51, 724.
      Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658.
      Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.
      Product Information
      CAS number691005-38-6
      FormDark brown solid
      Hill FormulaC₃₂H₃₆Cl₂Cu₂N₂O₂
      Chemical formulaC₃₂H₃₆Cl₂Cu₂N₂O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by Elemental Analysis
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot, freeze (≥-70°C). Stock solutions are stable for up to 12 months at ≥-70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      219334-10MG 04055977202137

      Documentation

      β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      β-Catenin/Tcf Inhibitor V, BC21 - CAS 691005-38-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      219334

      Références bibliographiques

      Aperçu de la référence bibliographique
      Tian, W., et al. 2012. Biochemistry 51, 724.
      Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658.
      Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-February-2017 JSW
      SynonymsCopper, di-µ-chlorobis[1-[(1-piperidinyl-κN)methyl]-2-naphthalenolato-κO]di-(9Cl), Wnt Pathway Inhibitor XV
      DescriptionA cell-permeable dimeric copper complex that competitively binds β-catenin and disrupts β-catenin/Tcf4 interaction reversibly (IC50 = 5.0 µM), and acts as a Wnt signaling inhibitor. Shown to induce preferential growth arrest in β-catenin overexpressing HCT116 colon cancer and HEK293 cells (≤ 10 µM), and downregulate mRNA expressions of c-Myc and cyclin D1. Reported to inhibit PP2C and proteasomal activities at higher concentrations (~50 µM).
      FormDark brown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number691005-38-6
      Chemical formulaC₃₂H₃₆Cl₂Cu₂N₂O₂
      Structure formulaStructure formula
      Purity≥95% by Elemental Analysis
      SolubilityDMSO (0.5 mg/ml). Poorly soluble in water.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot, freeze (≥-70°C). Stock solutions are stable for up to 12 months at ≥-70°C.
      Toxicity Standard Handling
      ReferencesTian, W., et al. 2012. Biochemistry 51, 724.
      Rogers, J.P., et al. 2006. J. Med. Chem. 49, 1658.
      Daniel, K.G., et al. 2004. Biochem. Pharmacol. 67, 1139.