343781 ω-Conotoxin GVIA, Conus geographus - CAS 106375-28-4 - Calbiochem

343781
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₁₂₀H₁₈₂N₃₈O₄₃S₆ 106375-28-4

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      US1343781-100UG
      Récupération des données relatives à la disponibilité...
      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
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          Bidon alu 100 μg
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          Description
          OverviewA neurotoxin that acts as an antagonist of voltage-activated N-type Ca2+ channels and of neurotransmitter release at neuronal synapses. Its antagonistic activity is attributed to a tyrosine residue at position 13. Does not bind to dihydropyridine- or verapamil-binding sites. Also reported to inhibit ATP-induced inward currents mediated by P2X2/X3 receptors (IC50 = 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors).
          Catalogue Number343781
          Brand Family Calbiochem®
          Synonymsω-CgTx GVIA
          References
          ReferencesLalo, U.V., et al. 2001. Brain Res. Bull. 54, 507.
          Kim, J.I., et al. 1995. Biochem. Biophys. Res. Commun. 206, 449.
          Abbott, J.R., and Litzinger, M.J. 1994. Int. J. Dev. Neurosci. 12, 43.
          Olivera, B.M., et al. 1991. J. Biol. Chem. 266, 22067.
          Protti, D.A., et al. 1991. Brain Res. 557, 336.
          Werth, J.L., et al. 1991. Mol. Pharmacol. 40, 742.
          Koyano, K., et al. 1987. Eur. J. Pharmacol. 135, 337.
          Abe, T., et al. 1986. Neurosci. Lett. 71, 203.
          Product Information
          CAS number106375-28-4
          ATP CompetitiveN
          DeclarationNot available for sale outside of the United States.
          FormLyophilized
          Hill FormulaC₁₂₀H₁₈₂N₃₈O₄₃S₆
          Chemical formulaC₁₂₀H₁₈₂N₃₈O₄₃S₆
          ReversibleN
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetVoltage-activated N-type Ca2+ channels
          Primary Target IC<sub>50</sub>21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide SequenceH-Cys¹-Lys-Ser-Hyp-Gly-Ser-Ser-Cys⁸-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys¹⁵-Cys¹⁶-Arg-Ser-Cys¹⁹-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys²⁶-Tyr-NH₂ (disulfide bonds: 1 → 16; 8 → 19; 15 → 26)
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 26/27/28

          Very toxic by inhalation, in contact with skin and if swallowed.
          S PhraseS: 45-36/37/39

          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Wear suitable protective clothing, gloves and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          End use certificateY
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          ω-Conotoxin GVIA, Conus geographus - CAS 106375-28-4 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          ω-Conotoxin GVIA, Conus geographus - CAS 106375-28-4 - Calbiochem Certificats d'analyse

          TitreNuméro de lot
          343781

          Références bibliographiques

          Aperçu de la référence bibliographique
          Lalo, U.V., et al. 2001. Brain Res. Bull. 54, 507.
          Kim, J.I., et al. 1995. Biochem. Biophys. Res. Commun. 206, 449.
          Abbott, J.R., and Litzinger, M.J. 1994. Int. J. Dev. Neurosci. 12, 43.
          Olivera, B.M., et al. 1991. J. Biol. Chem. 266, 22067.
          Protti, D.A., et al. 1991. Brain Res. 557, 336.
          Werth, J.L., et al. 1991. Mol. Pharmacol. 40, 742.
          Koyano, K., et al. 1987. Eur. J. Pharmacol. 135, 337.
          Abe, T., et al. 1986. Neurosci. Lett. 71, 203.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-June-2008 RFH
          Synonymsω-CgTx GVIA
          DescriptionA neurotoxin that acts as an antagonist of voltage-activated N-type Ca2+ channels and of neurotransmitter release at neuronal synapses. Its antagonistic activity is attributed to a tyrosine residue at position 13. Does not bind to dihydropyridine- or verapamil-binding sites. Also reported to inhibit ATP-induced inward currents mediated by P2X2/X3 receptors (IC50 = 21.2 nM for P2X3 and 3.84 µM for P2X2/X3 heterooligomeric receptors).
          FormLyophilized
          CAS number106375-28-4
          Chemical formulaC₁₂₀H₁₈₂N₃₈O₄₃S₆
          Peptide SequenceH-Cys¹-Lys-Ser-Hyp-Gly-Ser-Ser-Cys⁸-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys¹⁵-Cys¹⁶-Arg-Ser-Cys¹⁹-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys²⁶-Tyr-NH₂ (disulfide bonds: 1 → 16; 8 → 19; 15 → 26)
          Purity≥98% by HPLC
          SolubilityH₂O (250 µg/ml) or aqueous buffers
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Highly Toxic
          ReferencesLalo, U.V., et al. 2001. Brain Res. Bull. 54, 507.
          Kim, J.I., et al. 1995. Biochem. Biophys. Res. Commun. 206, 449.
          Abbott, J.R., and Litzinger, M.J. 1994. Int. J. Dev. Neurosci. 12, 43.
          Olivera, B.M., et al. 1991. J. Biol. Chem. 266, 22067.
          Protti, D.A., et al. 1991. Brain Res. 557, 336.
          Werth, J.L., et al. 1991. Mol. Pharmacol. 40, 742.
          Koyano, K., et al. 1987. Eur. J. Pharmacol. 135, 337.
          Abe, T., et al. 1986. Neurosci. Lett. 71, 203.