505227 (-)-Cytisine - CAS 485-35-8 - Calbiochem

505227
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₁₁H₁₄N₂O 485-35-8

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      5052270001
      Récupération des données relatives à la disponibilité...
      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
          Contacter le Service Clients
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          Flacon en verre 10 mg
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          Description
          OverviewA potent agonist selective for neuronal nAChRs (Ki = 2, 5890, 480, 329, and 492 nM at α4β2, α7, α3β4, α6/α4β4, α1β1γδ, respectively). Clinically used as a smoking cessation medicine and often used in addiction studies.
          Catalogue Number505227
          Brand Family Calbiochem®
          SynonymsnAChR Agonist, (-)-Cytisine, Nicotinic Acetylcholine Receptor Agonist, (-)-Cytisine, Baptitoxine, Sophorine
          References
          ReferencesChen, Y., et al., 2012. Br J Pharmacol. 165, 1006.
          West, R., 2011, N. Engl. J. Med. 365, 1193.
          Happe, K., et al., 1994. Neurosci. 62, 929.
          Reavill, C. et al., 1990. Neuropharmacol. 29, 619.
          Product Information
          CAS number485-35-8
          FormPale yellow solid
          Hill FormulaC₁₁H₁₄N₂O
          Chemical formulaC₁₁H₁₄N₂O
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetnAChR
          Primary Target K<sub>i</sub>2, 5890, 480, 329, and 492 nM at &alpha
          Purity≥99% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 35-36/37/38

          Causes severe burns.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 22-26-28.1-36/37/39-46-63

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          After contact with skin, wash immediately with plenty of water.
          Wear suitable protective clothing, gloves and eye/face protection.
          If swallowed, seek medical advice immediately and show this container or label.
          In case of accident by inhalation: remove casualty to fresh air and keep at rest.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          (-)-Cytisine - CAS 485-35-8 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Références bibliographiques

          Aperçu de la référence bibliographique
          Chen, Y., et al., 2012. Br J Pharmacol. 165, 1006.
          West, R., 2011, N. Engl. J. Med. 365, 1193.
          Happe, K., et al., 1994. Neurosci. 62, 929.
          Reavill, C. et al., 1990. Neuropharmacol. 29, 619.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-July-2013 JSW
          SynonymsnAChR Agonist, (-)-Cytisine, Nicotinic Acetylcholine Receptor Agonist, (-)-Cytisine, Baptitoxine, Sophorine
          DescriptionA potent agonist selective for neuronal nAChRs (Ki = 2, 5890, 480, 329, and 492 nM at α4β2, α7, α3β4, α6/α4β4, α1β1γδ, respectively). Clinically used as a smoking cessation medicine and often used in addiction studies.
          FormPale yellow solid
          CAS number485-35-8
          Chemical formulaC₁₁H₁₄N₂O
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityH₂O (100 mM)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic
          ReferencesChen, Y., et al., 2012. Br J Pharmacol. 165, 1006.
          West, R., 2011, N. Engl. J. Med. 365, 1193.
          Happe, K., et al., 1994. Neurosci. 62, 929.
          Reavill, C. et al., 1990. Neuropharmacol. 29, 619.