164603 3-Nitropropionic acid - CAS 504-88-1 - Calbiochem

A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA

164603
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₃H₅NO₄ 504-88-1

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      164603-50MG
      Récupération des données relatives à la disponibilité...
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      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
          Contacter le Service Clients
          Contact Customer Service

          		 Flacon en verre 50 mg
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          Description
          OverviewA cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38 mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.
          Catalogue Number164603
          Brand Family Calbiochem®
          Synonyms3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA
          References
          ReferencesBeal, M., et al. 1993, J. Neurosci. 13, 4181.
          Pang, Z., et al. 1997, J. Neuroscience 17, 3064.
          Huang, L., et al. 2006, J. Bio. Chem. 281, 5965.
          Garcia, M., et al. 2002, J. Neurosci. 22, 2174.
          Kim, G. W., et al. 2003, J. Neurosci. 23, 8733.
          Product Information
          CAS number504-88-1
          FormLight yellow powder
          Hill FormulaC₃H₅NO₄
          Chemical formulaC₃H₅NO₄
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥98% by NMR
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 25-36/37/38

          Toxic if swallowed.
          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          3-Nitropropionic acid - CAS 504-88-1 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          3-Nitropropionic acid - CAS 504-88-1 - Calbiochem Certificats d'analyse

          TitreNuméro de lot
          164603

          Références bibliographiques

          Aperçu de la référence bibliographique
          Beal, M., et al. 1993, J. Neurosci. 13, 4181.
          Pang, Z., et al. 1997, J. Neuroscience 17, 3064.
          Huang, L., et al. 2006, J. Bio. Chem. 281, 5965.
          Garcia, M., et al. 2002, J. Neurosci. 22, 2174.
          Kim, G. W., et al. 2003, J. Neurosci. 23, 8733.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-June-2012 JSW
          Synonyms3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA
          DescriptionA cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38 mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.
          FormLight yellow powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number504-88-1
          Chemical formulaC₃H₅NO₄
          Structure formulaStructure formula
          Purity≥98% by NMR
          SolubilityDMSO or Ethanol (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Toxic
          ReferencesBeal, M., et al. 1993, J. Neurosci. 13, 4181.
          Pang, Z., et al. 1997, J. Neuroscience 17, 3064.
          Huang, L., et al. 2006, J. Bio. Chem. 281, 5965.
          Garcia, M., et al. 2002, J. Neurosci. 22, 2174.
          Kim, G. W., et al. 2003, J. Neurosci. 23, 8733.