499610 (5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem

499610
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₁₉H₂₂O₇ 66018-38-0

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      499610-1MG
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      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
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          Flacon en verre 1 mg
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          Description
          OverviewA naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC50 = 8 nM) in an ATP-competitive and irreversible manner, while inhibiting MEK1 (IC50 = 411 nM) and three other MAPKKKs (IC50 ≥268 nM against MEKK1, ASK1, and MEKK4) only at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H2O2-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells. (5Z)-Zeaenol, Curvularia sp. (Cat. No. 499609) may serve as a negative control.
          Catalogue Number499610
          Brand Family Calbiochem®
          SynonymsTAK1 Inhibitor
          References
          ReferencesWindheim, M., et al. 2007. Biochem. J. 404, 179.
          Choo, M.K., et al. 2006. Mol. Cancer Ther. 5, 2970.
          Safwat, N., et al. 2005. Endocrinology 146, 4814.
          Ninomiya-Tsuji, J., et al. 2003. J. Biol. Chem. 278, 18485.
          Rawlins, P., et al. 1999. Int. J. Immunopharmacol. 21, 799.
          Product Information
          CAS number66018-38-0
          FormWhite solid
          Hill FormulaC₁₉H₂₂O₇
          Chemical formulaC₁₉H₂₂O₇
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          S PhraseS: 22-24/25-36/37/39

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing, gloves and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          (5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          (5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem Certificats d'analyse

          TitreNuméro de lot
          499610

          Références bibliographiques

          Aperçu de la référence bibliographique
          Windheim, M., et al. 2007. Biochem. J. 404, 179.
          Choo, M.K., et al. 2006. Mol. Cancer Ther. 5, 2970.
          Safwat, N., et al. 2005. Endocrinology 146, 4814.
          Ninomiya-Tsuji, J., et al. 2003. J. Biol. Chem. 278, 18485.
          Rawlins, P., et al. 1999. Int. J. Immunopharmacol. 21, 799.

          Brochure

          Titre
          Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision17-December-2018 JSW
          SynonymsTAK1 Inhibitor
          DescriptionA naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC50 = 8 nM) in an ATP-competitive and irreversible manner, while inhibiting MEK1 (IC50 = 411 nM) and three other MAPKKKs (IC50 ≥268 nM against MEKK1, ASK1, and MEKK4) only at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H2O2-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells. (5Z)-Zeaenol, Curvularia sp.(Cat. No. 499609) may serve as a negative control.
          FormWhite solid
          CAS number66018-38-0
          Chemical formulaC₁₉H₂₂O₇
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesWindheim, M., et al. 2007. Biochem. J. 404, 179.
          Choo, M.K., et al. 2006. Mol. Cancer Ther. 5, 2970.
          Safwat, N., et al. 2005. Endocrinology 146, 4814.
          Ninomiya-Tsuji, J., et al. 2003. J. Biol. Chem. 278, 18485.
          Rawlins, P., et al. 1999. Int. J. Immunopharmacol. 21, 799.