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182200 βARK1 Inhibitor - CAS 24269-96-3 - Calbiochem

182200
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Empirical FormulaCAS #
C₁₂H₉NO₆ 24269-96-3

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182200-5MG
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      Ampoule plast. 5 mg
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      Description
      OverviewA selective inhibitor of βARK1 (β-Adrenergic Receptor Kinase 1) (IC50 = 126 µM). Has no inhibitory activity against protein kinase A (PKA).
      Catalogue Number182200
      Brand Family Calbiochem®
      Synonymsβ-Adrenergic Receptor Kinase1 Inhibitor, GRK2 Inhibitor, Methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate
      References
      ReferencesIino, M., et al. 2002. J. Med. Chem. 45, 2150.
      Product Information
      CAS number24269-96-3
      ATP CompetitiveN
      FormYellow to orange solid
      Hill FormulaC₁₂H₉NO₆
      Chemical formulaC₁₂H₉NO₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetβARK1 (β-Adrenergic Receptor Kinase 1)
      Primary Target IC<sub>50</sub>126 µM against βARK1 (β-Adrenergic Receptor Kinase 1)
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      βARK1 Inhibitor - CAS 24269-96-3 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      βARK1 Inhibitor - CAS 24269-96-3 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      182200

      Références bibliographiques

      Aperçu de la référence bibliographique
      Iino, M., et al. 2002. J. Med. Chem. 45, 2150.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2016 JSW
      Synonymsβ-Adrenergic Receptor Kinase1 Inhibitor, GRK2 Inhibitor, Methyl 5-[2-(5-nitro-2-furyl)vinyl]-2-furoate
      DescriptionA selective inhibitor of β-adrenergic receptor kinase 1 (βARK1) (IC50 = 126 µM). Displays no inhibitory activity against protein kinase A (PKA). Identified from a group of existing compounds (not previously demonstrated to inhibit βARK1) using a two-step rational drug design protocol that included molecular modeling and comparative docking studies. Represents the first inhibitor that distinguishes between βARK1 and PKA, an enzyme with a similar adenine binding pocket. May be useful in the study of mechanisms involved in congestive heart failure where elevated levels of βARK1 desensitize agonist-bound β2-adrenergic receptors.
      FormYellow to orange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number24269-96-3
      Chemical formulaC₁₂H₉NO₆
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml) or Methanol
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesIino, M., et al. 2002. J. Med. Chem. 45, 2150.