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119147 Adenosine A1 Receptor Antagonist I, DPCPX - CAS 102146-07-6 - Calbiochem

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Synonymes: 8-Cyclopentyl-1,3-dipropylxanthine, CPX, PD-116,948

119147
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119147-25MG
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      Description
      OverviewA blood-brain barrier permeable xanthine derivative that acts as a highly selective antagonist of Adenosine A1 receptor (A1R; Ki = 3.9 nM, 130 nM, 1.0 µM, 4.0 µM for human A1, A2A, A2B, and A3 respectively). Exhibits about 1,000-fold higher affinity and a 30-fold greater selectivity for A1R when compared to theophylline. Shown to competitively antagonize the inhibition of adenylate cyclase activity via A1 adenosine receptors in rat fat cells and the stimulation of adenylate cyclase via A2 adenosine receptors in human platelets. Exhibits hypertensive properties.
      Catalogue Number119147
      Brand Family Calbiochem®
      Synonyms8-Cyclopentyl-1,3-dipropylxanthine, CPX, PD-116,948
      References
      ReferencesMigita, H., et al. 2008. J Neurosci Res. 86, 2820.
      Blood, A. B., et al. 2003. J Physiol. 553, , 935.
      Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.
      Ukena D., et al. 1993. Biochem Pharmacol. 45, 847.
      Product Information
      CAS number102146-07-6
      FormWhite solid
      Hill FormulaC₁₆H₂₄N₄O₂
      Chemical formulaC₁₆H₂₄N₄O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetA1
      Primary Target K<sub>i</sub>3.9 nM
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Adenosine A1 Receptor Antagonist I, DPCPX - CAS 102146-07-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      119147

      Références bibliographiques

      Aperçu de la référence bibliographique
      Migita, H., et al. 2008. J Neurosci Res. 86, 2820.
      Blood, A. B., et al. 2003. J Physiol. 553, , 935.
      Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.
      Ukena D., et al. 1993. Biochem Pharmacol. 45, 847.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-March-2013 JSW
      Synonyms8-Cyclopentyl-1,3-dipropylxanthine, CPX, PD-116,948
      DescriptionA blood-brain barrier permeable xanthine derivative that acts as a highly selective antagonist of Adenosine A1 receptor (A1R; Ki = 3.9 nM, 130 nM, 1.0 µM, 4.0 µM for human A1, A2A, A2B, and A3 respectively). Exhibits about 1,000-fold higher affinity and a 30-fold greater selectivity for A1R when compared to theophylline. Shown to competitively antagonize the inhibition of adenylate cyclase activity via A1 adenosine receptors in rat fat cells and the stimulation of adenylate cyclase via A2 adenosine receptors in human platelets. Exhibits hypertensive properties.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number102146-07-6
      Chemical formulaC₁₆H₂₄N₄O₂
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (5 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMigita, H., et al. 2008. J Neurosci Res. 86, 2820.
      Blood, A. B., et al. 2003. J Physiol. 553, , 935.
      Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.
      Ukena D., et al. 1993. Biochem Pharmacol. 45, 847.