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119139 Adenosine A₃ Receptor Agonist, 2-Cl-IB-MECA - CAS 163042-96-4 - Calbiochem

119139
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Empirical FormulaCAS #
C₁₈H₁₈ClIN₆O₄ 163042-96-4

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119139-2MG
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      Description
      OverviewAn adenosine analog that acts as a highly selective agonist of adenosine A3 receptor (Ki = 330 pM, 820 nM, 470 nM for A3, A1 and A2A, respectively). Shown to reduce ischemia reperfusion injury in mice and limit infarct size in isolated rat hearts. Shown to reversibly increase field excitatory postsynaptic potentials in hippocampal slices and exhibits excitatory effects on both evoked and spontaneous epileptiform discharges.
      Catalogue Number119139
      Brand Family Calbiochem®
      Synonyms2-Cl-IB-MECA, 2-chloro-IB-MECA
      References
      ReferencesKim, H. O., et al. 1994. J Med Chem. 37, 3614.
      Laudadio, M. A., et al. 2004. Epilepsy Res. 59, 83.
      Ge, Z.D., et al. 2006. J. Pharm. Exp. Ther. 319, 1200.
      Product Information
      CAS number163042-96-4
      FormWhite solid
      Hill FormulaC₁₈H₁₈ClIN₆O₄
      Chemical formulaC₁₈H₁₈ClIN₆O₄
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Adenosine A₃ Receptor Agonist, 2-Cl-IB-MECA - CAS 163042-96-4 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Adenosine A₃ Receptor Agonist, 2-Cl-IB-MECA - CAS 163042-96-4 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      119139

      Références bibliographiques

      Aperçu de la référence bibliographique
      Kim, H. O., et al. 1994. J Med Chem. 37, 3614.
      Laudadio, M. A., et al. 2004. Epilepsy Res. 59, 83.
      Ge, Z.D., et al. 2006. J. Pharm. Exp. Ther. 319, 1200.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2014 JSW
      Synonyms2-Cl-IB-MECA, 2-chloro-IB-MECA
      DescriptionAn adenosine analog that acts as a highly selective agonist of adenosine A3 receptor (Ki = 330 pM, 820 nM, 470 nM for A3, A1 and A2A, respectively). Shown to reduce ischemia reperfusion injury in mice and limit infarct size in isolated rat hearts. Shown to reversibly increase field excitatory postsynaptic potentials in hippocampal slices and exhibits excitatory effects on both evoked and spontaneous epileptiform discharges.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number163042-96-4
      Chemical formulaC₁₈H₁₈ClIN₆O₄
      Purity≥98% by HPLC
      SolubilityDMSO (20 mg/ml)
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesKim, H. O., et al. 1994. J Med Chem. 37, 3614.
      Laudadio, M. A., et al. 2004. Epilepsy Res. 59, 83.
      Ge, Z.D., et al. 2006. J. Pharm. Exp. Ther. 319, 1200.