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MABS45 Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2

This Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2 is validated for use in WB, IH for the detection of Annexin A1.

Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Signaling Research Sub-Category: GPCR, cAMP/cGMP & Calcium Signaling Gene Symbol: ANXA1, LPC1, ANX1, p35 UniProt Number: P04083
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MABS45
100 µg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS45
      DescriptionAnti-Annexin A1 Antibody, clone CPTC-ANXA1-2
      Alternate Names
      • annexin A1
      • chromobindin-9
      • annexin I (lipocortin I)
      • Lipocortin I
      • calpactin-2
      • Calpactin II
      • annexin-1
      • Phospholipase A2 inhibitory protein
      • Annexin I
      • Calpactin-2
      • Annexin-13
      • Chromobindin-9
      Background InformationAnnexin A1 (ANXA1) is a calcium and phospholipid binding protein almost entirely restricted to microglia in the CNS. During the peripheral inflammatory response, Annexin A1 is instrumental in the phagocytosis of apoptotic leukocytes. Annexin A1 restores the ability of microglia to differentiate between apoptotic and non-apoptotic cells during inflammatory activation. Current research is geared towards using Annexin A1 as a therapeutic target in neuroinflammation. Annexin A1 has also been shown to be influential in cancer development and proliferation.
      References
      Product Information
      FormatPurified
      Control
      • K562 cell lysate
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Annexin A1 Antibody, clone CPTC-ANXA1-2 is validated for use in WB, IH for the detection of Annexin A1.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A previous lot was used by an independent laboratory in IH. (http://antibodies.cancer.gov/antibodies/detail/CPTC-ANXA1-2)
      Biological Information
      ImmunogenFull length recombinant protein corresponding to human Annexin A1.

      Material obtained from the National Cancer Institute’s Clinical Proteomic Technologies for Cancer (CPTC) program
      CloneCPTC-ANXA1-2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryAnnexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq].
      Gene Symbol
      • ANXA1
      • LPC1
      • ANX1
      • p35
      Purification MethodProtein G
      UniProt Number
      UniProt SummaryFUNCTION: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.

      SUBUNIT STRUCTURE: Homodimer in placenta (20%); linked by transglutamylation. Interacts with DYSF (By similarity).

      SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection › cilium (By similarity). Basolateral cell membrane (By similarity). Note: Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar macrophages (By similarity).

      DOMAIN: A pair of annexin repeats may form one binding site for calcium and phospholipid.

      PTM: Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity.

      SEQUENCE SIMILARITIES: Belongs to the annexin family.

      Contains 4 annexin repeats.
      Molecular Weight~ 39 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in K562 cell lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected Annexin A1 on 10 µg of K562 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MABS45 04053252644870

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      Catégories

      Life Science Research > Antibodies and Assays > Primary Antibodies