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04-151 Anti-IFNAR-1 Antibody, clone MARI-5A3

Anti-IFNAR-1 Antibody, clone MARI-5A3 is an antibody against IFNAR-1 for use in FC, IP, WB, NEUT.

Anti-IFNAR-1 Antibody, clone MARI-5A3 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Inflammation & Immunology Research Sub-Category: Cytokines & Cytokine Receptors Gene Symbol: IFRC, IFNAR1, IFNBR, IFN-R-1, IFNAR, AVP, CRF2-1 UniProt Number: P33896
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04-151
100 µg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFC, IP, WB, NEUTMPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-151
      DescriptionAnti-IFNAR-1 Antibody, clone MARI-5A3
      Alternate Names
      • interferon (alpha, beta and omega) receptor 1
      • beta-type antiviral protein
      • alpha-type antiviral protein
      • Type I interferon receptor 1
      • Cytokine receptor family 2 member 1
      • interferon-beta receptor 1
      • Cytokine receptor class-II member 1
      • IFN-alpha-REC
      • interferon-alpha/beta receptor alpha chain
      • IFN-alpha/beta receptor 1
      • interferon alpha/beta receptor 1
      • human interferon-alpha receptor (HuIFN-alpha-Rec)
      Background InformationInterferon alpha/beta receptor 1 (IFNAR-1) is a single-pass type I membrane protein containing three fibronectin type-III domains and is a member of the type II cytokine receptor family. IFNAR-1 serves as an interferon receptor specific to interferons alpha and beta, a family of type I interferons critical to the promotion and the linking of adaptive and innate immune response. Type I interferons all bind to a heterodimeric receptor composed of two subunits, IFNAR-1 and IFNAR-2. The binding of the type I IFNs initializes tyrosine phosphorylation for several proteins such as; IFNR alpha/beta subunits, JAKs, STAT, and TYK2 proteins.
      References
      Product Information
      FormatPurified
      Control
      • BALB/c splenocytes
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-IFNAR-1 Antibody, clone MARI-5A3 is an antibody against IFNAR-1 for use in FC, IP, WB, NEUT.
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      • Western Blotting
      • Neutralizing
      Application NotesWestern Blot Analysis: A previous lot was used by an independent laboratory in WB. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)

      Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)

      Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)

      Neutralizing Assay: A previous lot was used by an independent laboratory in neutralization studies. (Sheehan, K., et al. (2006). Journal of Interferon & Cytokine Research. 26:804-819.)
      Biological Information
      ImmunogenRecombinant protein corresponding to the extracellular domain of mouse IFNAR-1.
      EpitopeExtracellular Domain
      CloneMARI-5A3
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes the extracellular domain of IFNAR-1.
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IFRC
      • IFNAR1
      • IFNBR
      • IFN-R-1
      • IFNAR
      • AVP
      • CRF2-1
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

      SEQUENCE SIMILARITIES: Belongs to the type II cytokine receptor family.

      Contains 3 fibronectin type-III domains.
      Molecular Weight63 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in BALB/c splenocytes.

      Flow Cytometry Analysis: 5 µg of this antibody detected IFNAR-1 in BALB/c splenocytes.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      04-151 04053252413544

      Documentation

      Anti-IFNAR-1 Antibody, clone MARI-5A3 FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-IFNAR-1 Antibody, clone MARI-5A3 Certificats d'analyse

      TitreNuméro de lot
      Anti-IFNAR-1, clone MARI-5A3 Monoclonal Antibody 2922305
      Anti-IFNAR-1, clone MARI-5A3 - 2282189 2282189
      Anti-IFNAR-1, clone MARI-5A3 - 3610574 3610574
      Anti-IFNAR-1, clone MARI-5A3 - 3883619 3883619
      Anti-IFNAR-1, clone MARI-5A3 - 3928022 3928022
      Anti-IFNAR-1, clone MARI-5A3 - 4197601 4197601
      Anti-IFNAR-1, clone MARI-5A3 - NRG1806876 NRG1806876
      Anti-IFNAR-1, clone MARI-5A3 -2514873 2514873
      Anti-IFNAR-1, clone MARI-5A3 -2578614 2578614
      Anti-IFNAR-1, clone MARI-5A3 -2587532 2587532
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